Deep Brain Ultrasound Ablation Thermal Dose Modeling with in Vivo Experimental Validation.

Autor: Zhao Z; Worcester Polytechnic Institute, Worcester, MA., Szewczyk B; Worcester Polytechnic Institute, Worcester, MA.; Department of Neurosurgery, Albany Medical Center, Albany, NY., Tarasek M; GE Global Research Center, Niskayuna, NY., Bales C; Worcester Polytechnic Institute, Worcester, MA., Wang Y; Worcester Polytechnic Institute, Worcester, MA., Liu M; Worcester Polytechnic Institute, Worcester, MA., Jiang Y; Worcester Polytechnic Institute, Worcester, MA., Bhushan C; GE Global Research Center, Niskayuna, NY., Fiveland E; GE Global Research Center, Niskayuna, NY., Campwala Z; Department of Neuroscience and Experimental Therapeutics, Albany Medical Center, Albany, NY., Trowbridge R; Department of Neuroscience and Experimental Therapeutics, Albany Medical Center, Albany, NY., Johansen PM; Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL., Olmsted Z; Department of Neuroscience and Experimental Therapeutics, Albany Medical Center, Albany, NY., Ghoshal G; Acoustic MedSystems, Inc., Savoy, IL., Heffter T; Acoustic MedSystems, Inc., Savoy, IL., Gandomi K; Worcester Polytechnic Institute, Worcester, MA., Tavakkolmoghaddam F; Worcester Polytechnic Institute, Worcester, MA., Nycz C; Worcester Polytechnic Institute, Worcester, MA., Jeannotte E; Animal Resources Facility, Albany Medical Center, Albany, NY., Mane S; Department of Neuroscience and Experimental Therapeutics, Albany Medical Center, Albany, NY., Nalwalk J; Department of Neuroscience and Experimental Therapeutics, Albany Medical Center, Albany, NY., Burdette EC; Acoustic MedSystems, Inc., Savoy, IL., Qian J; Department of Neurosurgery, Albany Medical Center, Albany, NY.; Department of Neuroscience and Experimental Therapeutics, Albany Medical Center, Albany, NY., Yeo D; GE Global Research Center, Niskayuna, NY., Pilitsis J; Department of Neurosurgery, Albany Medical Center, Albany, NY.; Department of Neuroscience and Experimental Therapeutics, Albany Medical Center, Albany, NY.; Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL., Fischer GS; Worcester Polytechnic Institute, Worcester, MA.
Jazyk: angličtina
Zdroj: ArXiv [ArXiv] 2024 Sep 05. Date of Electronic Publication: 2024 Sep 05.
Abstrakt: Intracorporeal needle-based therapeutic ultrasound (NBTU) is a minimally invasive option for intervening in malignant brain tumors, commonly used in thermal ablation procedures. This technique is suitable for both primary and metastatic cancers, utilizing a high-frequency alternating electric field (up to 10 MHz) to excite a piezoelectric transducer. The resulting rapid deformation of the transducer produces an acoustic wave that propagates through tissue, leading to localized high-temperature heating at the target tumor site and inducing rapid cell death. To optimize the design of NBTU transducers for thermal dose delivery during treatment, numerical modeling of the acoustic pressure field generated by the deforming piezoelectric transducer is frequently employed. The bioheat transfer process generated by the input pressure field is used to track the thermal propagation of the applicator over time. Magnetic resonance thermal imaging (MRTI) can be used to experimentally validate these models. Validation results using MRTI demonstrated the feasibility of this model, showing a consistent thermal propagation pattern. However, a thermal damage isodose map is more advantageous for evaluating therapeutic efficacy. To achieve a more accurate simulation based on the actual brain tissue environment, a new finite element method (FEM) simulation with enhanced damage evaluation capabilities was conducted. The results showed that the highest temperature and ablated volume differed between experimental and simulation results by 2.1884°C (3.71%) and 0.0631 cm 3 (5.74%), respectively. The lowest Pearson correlation coefficient (PCC) for peak temperature was 0.7117, and the lowest Dice coefficient for the ablated area was 0.7021, indicating a good agreement in accuracy between simulation and experiment.
Databáze: MEDLINE
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