Anticancer Potential of Pineapple and its Bioactive Compound Bromelain.

Autor:	Kumar D; College of Pharmacy, Pt BD Sharma University of Health Sciences, Rohtak 124001, India., Suchitra; College of Pharmacy, Pt BD Sharma University of Health Sciences, Rohtak 124001, India., Mundlia J; College of Pharmacy, Pt BD Sharma University of Health Sciences, Rohtak 124001, India., Yadav SK; B.S. Anangpuria Institute of Pharmacy, Faridabad, Haryana 121004, India., Yadav D; B.S. Anangpuria Institute of Pharmacy, Faridabad, Haryana 121004, India., Aggarwal N; MM College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), 133207 Mullana, India., Chopra H; Department of Biosciences, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, 602105 Chennai, Tamil Nadu, India., Kumar V; College of Pharmacy, Pt BD Sharma University of Health Sciences, Rohtak 124001, India., Kamal MA; Joint Laboratory of Artificial Intelligence in Healthcare, Institutes for Systems Genetics and West China School of Nursing, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.; King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.; Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, Bangladesh.; Centre for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India.; Enzymoics, 7 Peterlee Place, Hebersham, NSW 2770; Novel Global Community Educational Foundation, Australia.
Jazyk:	angličtina
Zdroj:	Current pharmaceutical design [Curr Pharm Des] 2024 Sep 12. Date of Electronic Publication: 2024 Sep 12.
DOI:	10.2174/0113816128303910240713180835
Abstrakt:	Various ailments have been treated with pineapple [Ananas comosus (L.) Merr.] throughout medicinal history. Pineapple and its bioactive compound bromelain possess health-promoting benefits. Detailed information on the chemotherapeutic activities of pineapple and its bioactive compound bromelain is provided in this review, which analyses the current literature regarding their therapeutic potential in cancer. Research on disease models in cell cultures is the focus of much of the existing research. Several studies have demonstrated the benefits of pineapple extract and bromelain for in vitro and in vivo cancer models. Preliminary animal model results show promise, but they must be translated into the clinical setting. Research on these compounds represents a promising future direction and may be well-tolerated. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
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