Light sampling behaviour regulates circadian entrainment in mice.

Autor: Steel LCE; Sir Jules Thorn Sleep and Circadian Neuroscience Institute (SCNi), Kavli Institute for Nanoscience Discovery, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Tam SKE; Duke Kunshan University, Kunshan, Jiangsu, China., Brown LA; Research IT, University of Oxford, Oxford, UK., Foster RG; Sir Jules Thorn Sleep and Circadian Neuroscience Institute (SCNi), Kavli Institute for Nanoscience Discovery, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Peirson SN; Sir Jules Thorn Sleep and Circadian Neuroscience Institute (SCNi), Kavli Institute for Nanoscience Discovery, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK. stuart.peirson@eye.ox.ac.uk.
Jazyk: angličtina
Zdroj: BMC biology [BMC Biol] 2024 Sep 16; Vol. 22 (1), pp. 208. Date of Electronic Publication: 2024 Sep 16.
DOI: 10.1186/s12915-024-01995-x
Abstrakt: Background: The natural light environment is far more complex than that experienced by animals under laboratory conditions. As a burrowing species, wild mice are able to self-modulate their light exposure, a concept known as light environment sampling behaviour. By contrast, under laboratory conditions mice have little opportunity to exhibit this behaviour. To address this issue, here we introduce a simple nestbox paradigm to allow mice to self-modulate their light environment. Dark nestboxes fitted with passive infrared sensors were used to monitor locomotor activity, circadian entrainment, decision making and light environment sampling behaviour.
Results: Under these conditions, mice significantly reduce their light exposure to an average of just 0.8 h across a 24 h period. In addition, mice show a distinct pattern of light environment sampling behaviour, with peaks at dawn and dusk under a ramped light dark cycle. Furthermore, we show that the timing of light environment sampling behaviour depends upon endogenous circadian rhythms and is abolished in mice lacking a circadian clock, indicating a feedback loop between light, the circadian clock and behaviour.
Conclusions: Our results highlight the important role of behaviour in modifying the light signals available for circadian entrainment under natural conditions.
(© 2024. The Author(s).)
Databáze: MEDLINE
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