Synthesis and Application of New Selanylfullerene Derivatives as Photosensitizers for Photodynamic Therapy.

Autor: Soares LC; LABSELEN-NanoBios - Department of Chemistry, Federal University of Santa Maria, Santa Maria, CEP 97105-900, Rio Grande do Sul, Brazil., Vargas J; LABSELEN-NanoBios - Department of Chemistry, Federal University of Santa Maria, Santa Maria, CEP 97105-900, Rio Grande do Sul, Brazil., Ravanello BB; LABSELEN-NanoBios - Department of Chemistry, Federal University of Santa Maria, Santa Maria, CEP 97105-900, Rio Grande do Sul, Brazil., Ilha V; LABSELEN-NanoBios - Department of Chemistry, Federal University of Santa Maria, Santa Maria, CEP 97105-900, Rio Grande do Sul, Brazil., Seus N; LASOL-CCQFA, Federal University of Pelotas, UFPel Pelotas, Rio Grande do Sul, CEP 96010-900, Brazil., Santos da Silva R; LABSELEN-NanoBios - Department of Chemistry, Federal University of Santa Maria, Santa Maria, CEP 97105-900, Rio Grande do Sul, Brazil., Alves D; LASOL-CCQFA, Federal University of Pelotas, UFPel Pelotas, Rio Grande do Sul, CEP 96010-900, Brazil., Dornelles L; LABSELEN-NanoBios - Department of Chemistry, Federal University of Santa Maria, Santa Maria, CEP 97105-900, Rio Grande do Sul, Brazil., Villetti MA; Department of Physics, Federal University of Santa Maria, CEP 97105-900, Santa Maria, Rio Grande do Sul, Brazil., da Rocha VN; Department of Physics, Federal University of Santa Maria, CEP 97105-900, Santa Maria, Rio Grande do Sul, Brazil., Piquini PC; Department of Physics, Federal University of Santa Maria, CEP 97105-900, Santa Maria, Rio Grande do Sul, Brazil., Rodrigues OED; LABSELEN-NanoBios - Department of Chemistry, Federal University of Santa Maria, Santa Maria, CEP 97105-900, Rio Grande do Sul, Brazil.
Jazyk: angličtina
Zdroj: Chemistry, an Asian journal [Chem Asian J] 2024 Sep 15, pp. e202400734. Date of Electronic Publication: 2024 Sep 15.
DOI: 10.1002/asia.202400734
Abstrakt: This study aims to describe the synthesis of a new class of selanylfullerene derivatives in a convergent strategy route, affording the desired products in a few steps and in good yields. C 60 compounds were evaluated as photosensitizers to be used in photodynamic therapy (PDT) via the generation of singlet oxygen ( 1 O 2 ), using the chemical trapping method. The photooxidation of the chemical probe1,3-diphenylisobenzofuran (DPBF) sensitized by selanylfullerenes followed a first-order kinetic and the values of singlet oxygen quantum yields (ΦΔ) are appropriate for its use in PDT. The electronic absorption spectra, and the intersystem crossing tax rates for the most prominent synthesized compounds were calculated using the density functional theory and the Marcus electron transfer theory, with the theoretical results confirming the experimental findings.
(© 2024 Wiley-VCH GmbH.)
Databáze: MEDLINE
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