Synthesis and application of new selanylfullerene derivatives as photosensitizers for photodynamic therapy.

Autor: Soares LC; Federal University of Santa Maria, chemistry, BRAZIL., Vargas J; Federal University of Santa Maria, chemistry, BRAZIL., Ravanello BB; Federal University of Santa Maria, chemistry, BRAZIL., Ilha V; Federal University of Santa Maria, chemistry, BRAZIL., Seus N; Federal University of Pelotas, chemistry, BRAZIL., Santos da Silva R; Federal University of Santa Maria, chemistry, BRAZIL., Alves D; Federal University of Pelotas, chemistry, BRAZIL., Dornelles L; Federal University of Santa Maria, chemistry, BRAZIL., Villetti MA; Federal University of Santa Maria, physics, BRAZIL., da Rocha VN; Federal University of Santa Maria, physics, BRAZIL., Piquini PC; Federal University of Santa Maria, physics, BRAZIL., Dorneles Rodrigues OE; Universidade Federal de Santa Maria, Chemistry, Av. Roraima, 1000 - Pt�dio 18, sala 2218, Bairro Camobi, 97105-900, Santa Maria, BRAZIL.
Jazyk: angličtina
Zdroj: Chemistry, an Asian journal [Chem Asian J] 2024 Sep 15, pp. e202400734. Date of Electronic Publication: 2024 Sep 15.
DOI: 10.1002/asia.202400734
Abstrakt: This study aims to describe the synthesis of a new class of selanylfullerene derivatives in a convergent strategy route, affording the desired products in a few steps and in good yields. C60 compounds were evaluated as photosensitizers to be used in photodynamic therapy (PDT) via the generation of singlet oxygen (1O2), using the chemical trapping method. The photooxidation of the chemical probe1,3-diphenylisobenzofuran (DPBF) sensitized by selanylfullerenes followed a first-order kinetic and the values of singlet oxygen quantum yields (ΦΔ) are appropriate for its use in PDT. The electronic absorption spectra, and the intersystem crossing tax rates for the most prominent synthesized compounds were calculated using the density functional theory and the Marcus electron transfer theory, with the theoretical results confirming the experimental findings.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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