An anti-neoplastic tale of metformin through its transport.

Autor: Bhati FK; Biotechnology Research and Innovation Council - National Centre for Cell Science (BRIC- NCCS), Savitribai Phule Pune University Campus, Ganeshkhind, Pune 411 007, India., Bhat MK; Biotechnology Research and Innovation Council - National Centre for Cell Science (BRIC- NCCS), Savitribai Phule Pune University Campus, Ganeshkhind, Pune 411 007, India. Electronic address: manojkbhat@nccs.res.in.
Jazyk: angličtina
Zdroj: Life sciences [Life Sci] 2024 Nov 15; Vol. 357, pp. 123060. Date of Electronic Publication: 2024 Sep 14.
DOI: 10.1016/j.lfs.2024.123060
Abstrakt: Metformin is an attractive candidate drug among all the repurposed drugs for cancer. Extensive preclinical and clinical research has evaluated its efficacy in cancer therapy, revealing a mixed outcome in clinical settings. To fully exploit metformin's therapeutic potential, understanding cellular factors relevant to its transport and accumulation in cancer cells needs to be understood. This review highlights the relevance of metformin transporter status towards its anti-cancer potential. Metformin transporters are regulated at pre-transcriptional, transcriptional, and post-translational levels. Moreover, the tumour microenvironment can also influence metformin accumulation in cancer cells. Also, Metformin treatment can regulate its transporters by altering global DNA methylation, protein acetylation, and transcription factors. Importantly, metformin transporters not only influence chemotherapeutic drug toxicity but are also associated with the prognosis and survival of individuals having cancer. Strategic decisions based on the expression and regulation of metformin transporters holds promise for its therapeutic implications and relevance.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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