Study of pediatric invasive pneumococcal disease in the 13-pneumococcal conjugated vaccine era.

Autor: Garrido-Jareño M; Microbiology Department, University and Polytechnic Hospital La Fe Valencia, Spain; Severe Infection Research Group, Health Research Institute Hospital La Fe Valencia, Spain. Electronic address: ma.garridojj@gmail.com., Roig-Sena FJ; General Directorate of Public Health, Council of Universal Healthcare and Public Health, Regional Government of Valencia Valencia, Spain., Pérez-Pérez E; General Directorate of Public Health, Council of Universal Healthcare and Public Health, Regional Government of Valencia Valencia, Spain., Gil-Brusola A; Microbiology Department, University and Polytechnic Hospital La Fe Valencia, Spain; Severe Infection Research Group, Health Research Institute Hospital La Fe Valencia, Spain., López-Hontangas JL; Microbiology Department, University and Polytechnic Hospital La Fe Valencia, Spain; Severe Infection Research Group, Health Research Institute Hospital La Fe Valencia, Spain., Valentín-Gómez E; Severe Infection Research Group, Health Research Institute Hospital La Fe Valencia, Spain; GMCA Research Unit, Department of Microbiology and Ecology, University of Valencia Valencia, Spain., Pineda-Lucena A; Molecular Therapeutics Program, Center for Applied Medical Research, University of Navarra Pamplona, Spain., Pemán J; Microbiology Department, University and Polytechnic Hospital La Fe Valencia, Spain; Severe Infection Research Group, Health Research Institute Hospital La Fe Valencia, Spain.
Jazyk: angličtina
Zdroj: Diagnostic microbiology and infectious disease [Diagn Microbiol Infect Dis] 2024 Dec; Vol. 110 (4), pp. 116532. Date of Electronic Publication: 2024 Sep 07.
DOI: 10.1016/j.diagmicrobio.2024.116532
Abstrakt: Background: Invasive pneumococcal disease (IPD) remains a significant concern among children under 5, despite vaccination efforts. This study assessed IPD prevalence and associated risks in pediatric population.
Methods: An observational, retrospective, multicenter study in Comunidad Valenciana, Spain, of IPD cases in children under 13 from January 2012 to September 2022. Data from the CV Microbiology Surveillance Network (RedMIVA) and medical records were reviewed.
Results: A total of 379 IPD cases in 377 patients were analyzed, predominantly males (54.11 %) under 5 (81.17 %). PCV13 vaccination notably reduced PCV13-serotypes IPD (p=0.0002), except serotype 3. Pneumonia was common, with half having underlying conditions (50.40 %). Worse outcomes occurred in patients with neurological disorders (ANOVA, p=0.57). Vaccine failures often involved underlying conditions (63 %) and serotypes 3 and 19A. Immunodeficiencies may relate to recurrent IPD, but evidence is limited.
Conclusion: Despite vaccination, IPD still impacts children, influenced by immunological status, affecting severity and mortality.
Competing Interests: Declaration of competing interest Marta Garrido-Jareño (MGJ): conceived of the presented idea and wrote the manuscript. Francisco Javier Roig-Sena (FJRS): provided part of the epidemiological data of the patients to carry out the study. Elvira Pérez-Pérez (EPP): provided part of the epidemiological data of the patients to carry out the study. Ana Gil-Brusola (AGB): conceived of the presented idea and were involved in planning and supervised the work. José Luis López-Hontangas (JLLH): discussed the results and contributed to the final manuscript. Eulogio Valentín-Gómez (EVG): discussed the results and contributed to the final manuscript. Antonio Pineda-Lucena (APL): discussed the results and contributed to the final manuscript. Javier Pemán (JP): conceived the study and were in charge of overall direction and planning. Discussed the results and contributed to the final manuscript.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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