Subcutaneous adipose tissue radiodensity: An emerging risk factor for severe COVID-19.

Autor: Padilha DMH; Department of Anesthesiology, Oncology and Radiology, School of Medical Sciences, University of Campinas, Campinas SP, Brazil; Nestlé Health Science, Lausanne, Switzerland., Mendes MCS; Department of Anesthesiology, Oncology and Radiology, School of Medical Sciences, University of Campinas, Campinas SP, Brazil; Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas SP, Brazil., Takahashi MES; Institute of Physics 'Gleb Wataghin', University of Campinas, Campinas SP, Brazil., Lascala F; Department of Anesthesiology, Oncology and Radiology, School of Medical Sciences, University of Campinas, Campinas SP, Brazil., Silveira MN; Department of Anesthesiology, Oncology and Radiology, School of Medical Sciences, University of Campinas, Campinas SP, Brazil., Pozzuto L; Department of Anesthesiology, Oncology and Radiology, School of Medical Sciences, University of Campinas, Campinas SP, Brazil., Carrilho LAO; Department of Anesthesiology, Oncology and Radiology, School of Medical Sciences, University of Campinas, Campinas SP, Brazil., Guerra LD; Department of Anesthesiology, Oncology and Radiology, School of Medical Sciences, University of Campinas, Campinas SP, Brazil., Moreira RCL; Department of Anesthesiology, Oncology and Radiology, School of Medical Sciences, University of Campinas, Campinas SP, Brazil., Branbilla SR; Department of Anesthesiology, Oncology and Radiology, School of Medical Sciences, University of Campinas, Campinas SP, Brazil., Ramos CD; Department of Anesthesiology, Oncology and Radiology, School of Medical Sciences, University of Campinas, Campinas SP, Brazil., Carvalheira JBC; Department of Anesthesiology, Oncology and Radiology, School of Medical Sciences, University of Campinas, Campinas SP, Brazil. Electronic address: jbcc@unicamp.br.
Jazyk: angličtina
Zdroj: Nutrition (Burbank, Los Angeles County, Calif.) [Nutrition] 2024 Dec; Vol. 128, pp. 112561. Date of Electronic Publication: 2024 Aug 20.
DOI: 10.1016/j.nut.2024.112561
Abstrakt: Background: Adipose tissue radiodensity and metabolic activity may influence COVID-19 outcomes. This study evaluated the association between adipose tissue characteristics and clinical outcomes in COVID-19 patients.
Methods: Two retrospective cohorts of hospitalized COVID-19 patients were analyzed. Subcutaneous adipose tissue radiodensity (SATR) and visceral adipose tissue radiodensity were assessed by computed tomography. Fluorine-18-labelled fluorodeoxyglucose PET/computed tomography measured adipose tissue metabolic activity. Associations with mortality, length of stay, ventilation requirement, and complications were examined using regression analyses.
Results: High SATR was independently associated with increased mortality risk (OR: 2.70; P = 0.033), longer hospitalization (P < 0.001), higher rates of mechanical ventilation (P = 0.007), and complications: acute kidney injury (P = 0.001), secondary infection (P = 0.007), shock (P = 0.010), and pulmonary embolism (P = 0.011). SATR positively correlated with SAT glucose uptake (ρ = 0.52) and negatively with leptin levels (ρ = -0.48).
Conclusions: Elevated SATR at COVID-19 diagnosis predicts disease severity and worse outcomes. SATR is a potential prognostic biomarker for acute and chronic inflammatory conditions.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this article.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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