Structure-function coupling in highly sampled individual brains.

Autor:	Rajesh A; Department of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St. Louis, MO 63110, USA., Seider NA; Department of Psychiatry, Washington University School of Medicine, 660 S Euclid Ave, St. Louis, MO 63110, USA., Newbold DJ; Department of Neurology, New York Langone Medical Center, 550 First Avenue, New York, NY, 10016, USA., Adeyemo B; Department of Neurology, Washington University School of Medicine, 660 S. Euclid Ave.St. Louis, MO 63110, USA., Marek S; Department of Psychiatry, Washington University School of Medicine, 660 S Euclid Ave, St. Louis, MO 63110, USA., Greene DJ; Department of Cognitive Science, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92037, USA., Snyder AZ; Department of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St. Louis, MO 63110, USA.; Department of Neurology, New York Langone Medical Center, 550 First Avenue, New York, NY, 10016, USA., Shimony JS; Department of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St. Louis, MO 63110, USA.; Department of Neuroscience, Washington University, 660 S. Euclid Ave.St. Louis, MO 63110, USA., Laumann TO; Department of Psychiatry, Washington University School of Medicine, 660 S Euclid Ave, St. Louis, MO 63110, USA., Dosenbach NUF; Department of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St. Louis, MO 63110, USA.; Department of Neurology, Washington University School of Medicine, 660 S. Euclid Ave.St. Louis, MO 63110, USA.; Department of Pediatrics, Washington University School of Medicine, 660 S. Euclid Ave.St. Louis, MO 63110, USA.; Department of Biomedical Engineering, Washington University, 1 Brookings Drive, St. Louis, MO 63130, USA.; Program in Occupational Therapy, Washington University, 4444 Forest Park Ave, St. Louis, MO 63108, USA., Gordon EM; Department of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St. Louis, MO 63110, USA.
Jazyk:	angličtina
Zdroj:	Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2024 Sep 03; Vol. 34 (9).
DOI:	10.1093/cercor/bhae361
Abstrakt:	Structural connectivity (SC) between distant regions of the brain support synchronized function known as functional connectivity (FC) and give rise to the large-scale brain networks that enable cognition and behavior. Understanding how SC enables FC is important to understand how injuries to SC may alter brain function and cognition. Previous work evaluating whole-brain SC-FC relationships showed that SC explained FC well in unimodal visual and motor areas, but only weakly in association areas, suggesting a unimodal-heteromodal gradient organization of SC-FC coupling. However, this work was conducted in group-averaged SC/FC data. Thus, it could not account for inter-individual variability in the locations of cortical areas and white matter tracts. We evaluated the correspondence of SC and FC within three highly sampled healthy participants. For each participant, we collected 78 min of diffusion-weighted MRI for SC and 360 min of resting state fMRI for FC. We found that FC was best explained by SC in visual and motor systems, as well as in anterior and posterior cingulate regions. A unimodal-to-heteromodal gradient could not fully explain SC-FC coupling. We conclude that the SC-FC coupling of the anterior-posterior cingulate circuit is more similar to unimodal areas than to heteromodal areas. (© The Author(s) 2024. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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