Effectiveness of topical 25% silver nitrate solution followed by 5% fluoride varnish compared to 38% silver diamine fluoride in arresting and preventing dental caries among beta-thalassemia major patients: A randomized clinical trial.

Autor: Kayasth J; Dept. of Public Health Dentistry, Post Graduate Institute of Dental Sciences, Rohtak, Haryana, India., Yadav V; Dept. of Public Health Dentistry, Post Graduate Institute of Dental Sciences, Rohtak, Haryana, India. Electronic address: vipulyadavv.97@gmail.com., Bc M; Dept. of Public Health Dentistry, Post Graduate Institute of Dental Sciences, Rohtak, Haryana, India., Atri S; Department of Medicine (Hematology), PGIMS Pt B.D. Sharma UHS Rohtak (Co-Supervisor), India., Kumar A; Dept. of Public Health Dentistry, Post Graduate Institute of Dental Sciences, Rohtak, Haryana, India., Goel S; Dept. of Public Health Dentistry, Post Graduate Institute of Dental Sciences, Rohtak, Haryana, India., Sabbarwal B; Dept. of Public Health Dentistry, Post Graduate Institute of Dental Sciences, Rohtak, Haryana, India.
Jazyk: angličtina
Zdroj: Journal of dentistry [J Dent] 2024 Nov; Vol. 150, pp. 105349. Date of Electronic Publication: 2024 Sep 12.
DOI: 10.1016/j.jdent.2024.105349
Abstrakt: Introduction: This is the first randomized non-inferiority clinical trial in the evidence literature to examine the effectiveness of topical 25% silver nitrate (SN) followed by 5% sodium fluoride (NaF) varnish is not much worse or acceptable to 38% silver diamine fluoride (SDF) in preventing and arresting dental caries among Beta-Thalassemia Major (BTM) patients.
Method: 170 BTM participants aged 18 years and older with at least 1 or more active carious lesions were randomly allocated into 2 groups (1:1). 25% silver nitrate solution application followed by 5% NaF varnish was administered to Group I, and Group II received 38% SDF. The Nyvad criteria and DMFT index were used to assess caries arrest and prevention among both groups at 3- and 6-months interval.
Results: Caries arrest rate at 3 months was significantly higher in Group I (83.10%) when compared to Group II (76.16%) (p<0.05). While at 6 months, both the groups were comparable with arrest rate (76.16%) (p>0.05). The caries increment was comparable among both groups at 3 months, while at 6 months, caries increment was almost half in SN with NaF group compared to SDF group (p>0.05). Kaplan-Meir survival estimated the median survival time for caries increment was 17 and 39 weeks for Group I and 15 and 36 weeks for Group II at 3 and 6 months, respectively.
Conclusion: One time application of 25% SN followed by 5% NaF is no worse than a 38% SDF in arresting and preventing dental caries among Thalassemia Major participants at 3 and 6 months.
Clinical Significance: The study provides clinicians with a cost-effective, safer, readily available, non-invasive treatment option (25% SN followed by 5% NaF) for caries management.
Competing Interests: Declaration of competing interest The authors have no conflicts of interest to declare.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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