Prevalence of methicillin-resistant Staphylococcus aureus (MRSA) harboring mupirocin and biocide resistance genes in a large health care system.

Autor: Rosa R; Infection Prevention and Control Program, Jackson Health System, Miami, FL. Electronic address: rossana.rosa@jhsmiami.org., de Paula Baptista R; Division of Infectious Diseases, Houston Methodist Hospital, Houston, TX; Center for Infectious Diseases, Houston Methodist Research Institute, Houston, TX; Department of Medicine, Weill Cornell Medical College, New York City, NY., Tran TT; Division of Infectious Diseases, Houston Methodist Hospital, Houston, TX; Center for Infectious Diseases, Houston Methodist Research Institute, Houston, TX; Department of Medicine, Weill Cornell Medical College, New York City, NY., Cifuentes RO; Division of Infectious Diseases, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL., Manzanillo K; Infection Prevention and Control Program, Jackson Health System, Miami, FL., Rosello G; Infection Prevention and Control Program, Jackson Health System, Miami, FL., Ghaemmaghami C; Executive Office, Jackson Health System, Miami, FL., Zambrana D; Executive Office, Jackson Health System, Miami, FL., Martinez OV; Microbiology Section, Jackson Memorial Hospital, Miami, FL; Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine, Miami, FL., Arias CA; Division of Infectious Diseases, Houston Methodist Hospital, Houston, TX; Center for Infectious Diseases, Houston Methodist Research Institute, Houston, TX; Department of Medicine, Weill Cornell Medical College, New York City, NY., Abbo LM; Infection Prevention and Control Program, Jackson Health System, Miami, FL; Division of Infectious Diseases, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL.
Jazyk: angličtina
Zdroj: American journal of infection control [Am J Infect Control] 2025 Jan; Vol. 53 (1), pp. 105-109. Date of Electronic Publication: 2024 Sep 12.
DOI: 10.1016/j.ajic.2024.09.002
Abstrakt: Background: We aimed to determine the prevalence of genes associated with high-level mupirocin and biocide resistance in methicillin-resistant Staphylococcus aureus (MRSA) isolates among hospitalized patients and to characterize their genomic and epidemiologic features.
Methods: Study conducted on an integrated health system. Clinical cultures with MRSA from hospitalized patients collected between March 1, 2023, and January 20, 2024 underwent prospective whole-genome sequencing, including assessment for the presence of markers of resistance against mupirocin (mupA) and biocides (qac). Demographic and clinical characteristics were reviewed.
Results: We analyzed 463 MRSA isolates. The overall prevalence of mupA(+), qacA(+), and qacC(+) genes was 22.0%, 2.4%, and 19.0%, respectively. Most mupA(+) isolates belonged to ST8, but ST8732 (a novel variant of ST8) had the highest prevalence of mupA(+) isolates at 95%. Patients mupA(+) were older, and none of the isolates from pediatric patients harbored this gene.
Discussion: Through prospective whole-genome sequencing of MRSA isolates, we detected a prevalence of genes conferring mupirocin resistance considerably higher than previously reported, particularly among MRSA ST8 variants.
Conclusions: Our findings highlight the need for monitoring resistance to agents used for the prevention of S aureus infections, as these trends have implications for infection prevention programs and public health at large.
(Copyright © 2024 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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