The spread of chemical biology into chromatin.

Autor:	Hegazi E; Department of Chemistry, Princeton University, Princeton, New Jersey, USA., Muir TW; Department of Chemistry, Princeton University, Princeton, New Jersey, USA. Electronic address: muir@princeton.edu.
Jazyk:	angličtina
Zdroj:	The Journal of biological chemistry [J Biol Chem] 2024 Nov; Vol. 300 (11), pp. 107776. Date of Electronic Publication: 2024 Sep 12.
DOI:	10.1016/j.jbc.2024.107776
Abstrakt:	Understanding the molecular mechanisms underlying chromatin regulation, the complexity of which seems to deepen with each passing year, requires a multidisciplinary approach. While many different tools have been brought to bear in this area, here we focus on those that have emerged from the field of chemical biology. We discuss methods that allow the generation of what is now commonly referred to as "designer chromatin," a term that was coined by the late C. David (Dave) Allis. Among Dave's many talents was a remarkable ability to "brand" a nascent area (or concept) such that it was immediately relatable to the broader field. This also had the entirely intentional effect of drawing more people into the area, something that as this brief review attempts to convey has certainly happened when it comes to getting chemists involved in chromatin research. Competing Interests: Conflict of interest The authors declare that they have no conflicts of interest with the contents of this article. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu