Cynbungenins A-K, structurally diverse steroids with cytotoxic activity from the roots of Cynanchum bungei Decne.

Autor: Li XS; Guangdong Engineering Technology Research Center for the Development and Utilization of Mangrove Wetland Medicinal Resources, Key Lab of Zhanjiang for R&D Marine Microbial Resources in the Beibu Gulf Rim, and School of Ocean and Tropical Medicine, Guangdong Medical University, Zhanjiang, 524023, PR China; Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs, and School of Pharmacy, Guangdong Medical University, Dongguan, 523808, PR China. Electronic address: lixiaosan2018@163.com., Liu MS; Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs, and School of Pharmacy, Guangdong Medical University, Dongguan, 523808, PR China., Feng WB; Guangdong Engineering Technology Research Center for the Development and Utilization of Mangrove Wetland Medicinal Resources, Key Lab of Zhanjiang for R&D Marine Microbial Resources in the Beibu Gulf Rim, and School of Ocean and Tropical Medicine, Guangdong Medical University, Zhanjiang, 524023, PR China., Luo YH; Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs, and School of Pharmacy, Guangdong Medical University, Dongguan, 523808, PR China; School of Physical Science and Technology, ShanghaiTech University, Shanghai, 201210, PR China., Yuan WB; Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs, and School of Pharmacy, Guangdong Medical University, Dongguan, 523808, PR China., Li TT; Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs, and School of Pharmacy, Guangdong Medical University, Dongguan, 523808, PR China., Peng XF; Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs, and School of Pharmacy, Guangdong Medical University, Dongguan, 523808, PR China., Huang YM; Guangdong Engineering Technology Research Center for the Development and Utilization of Mangrove Wetland Medicinal Resources, Key Lab of Zhanjiang for R&D Marine Microbial Resources in the Beibu Gulf Rim, and School of Ocean and Tropical Medicine, Guangdong Medical University, Zhanjiang, 524023, PR China., Yang XM; Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs, and School of Pharmacy, Guangdong Medical University, Dongguan, 523808, PR China. Electronic address: xuemeiyang131@163.com., Luo H; Guangdong Engineering Technology Research Center for the Development and Utilization of Mangrove Wetland Medicinal Resources, Key Lab of Zhanjiang for R&D Marine Microbial Resources in the Beibu Gulf Rim, and School of Ocean and Tropical Medicine, Guangdong Medical University, Zhanjiang, 524023, PR China; Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs, and School of Pharmacy, Guangdong Medical University, Dongguan, 523808, PR China. Electronic address: luohui@gdmu.edu.cn.
Jazyk: angličtina
Zdroj: Phytochemistry [Phytochemistry] 2025 Jan; Vol. 229, pp. 114287. Date of Electronic Publication: 2024 Sep 12.
DOI: 10.1016/j.phytochem.2024.114287
Abstrakt: Chemical investigation of the acid hydrolysate of Cynanchum bungei roots led to the isolation of eleven undescribed steroids, namely cynbungenins A-K (1-11), and seven previously described analogues (12-18). The complete structures of these compounds were elucidated using the comprehensive spectroscopic analyses and reference data. Structurally, compounds 1 and 2 represent the first example of androstane-type steroids found in the Cynanchum plants, and compounds 3-6 and 12 are characterized as pregnane-type steroids with a rare 8,14-seco-steroid core. In the cytotoxic activity assay, compound 16 displayed the strongest cytotoxic effect against MCF-7, HCT-116, HeLa, and HepG2 cancer cell lines, with IC 50 values of 9.98-16.42 μM, and further research indicated that it induced both apoptosis and cell cycle arrest in the G0/G1 phase in a dose-dependent manner toward HepG2 cells.
Competing Interests: Declaration of competing interest All authors declare that No conflict of interest exists.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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