Optimizing distal and proximal splenic artery embolization with patient-specific computational fluid dynamics.

Autor: Tatari Y; Department of Mechanical Engineering, University of Utah, Salt Lake City, UT, USA; Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, UT, USA. Electronic address: younes.tatari@sci.utah.edu., Smith TA; Department of Radiology, University of Utah, Salt Lake City, UT, USA. Electronic address: tyler.a.smith@hsc.utah.edu., Hu J; Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC, USA. Electronic address: jhu35@ncsu.edu., Arzani A; Department of Mechanical Engineering, University of Utah, Salt Lake City, UT, USA; Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, UT, USA. Electronic address: amir.arzani@sci.utah.edu.
Jazyk: angličtina
Zdroj: Journal of biomechanics [J Biomech] 2024 Nov; Vol. 176, pp. 112320. Date of Electronic Publication: 2024 Sep 12.
DOI: 10.1016/j.jbiomech.2024.112320
Abstrakt: Splenic artery embolization (SAE) has become a favored alternative to splenectomy, offering a less invasive intervention for injured spleens while preserving spleen function. However, our understanding of the role that hemodynamics plays during embolization remains limited. In this study, we utilized patient-specific computational fluid dynamics (CFD) simulations to study distal and proximal embolization strategies commonly used in SAE. Detailed 3D computer models were constructed considering the descending aorta, various major visceral arteries, and the iliac arteries. Subsequently, the blood flow and pressure associated with different coil placement locations in proximal embolization were studied considering the collateral vessels. Coil induced variations in pressure fields were quantified and compared to baseline. The coil induced flow stagnation was also quantified with particle residence time. Distal embolization was modeled with Lagrangian particle tracking and the effect of particle size, release location, and timing on embolization outcome was studied. Our findings highlight the crucial role of collateral vessels in maintaining blood supply to the spleen following proximal embolization. It was demonstrated that coil location can affect distal pressure and that strategic coil placement guided by patient-specific CFD simulations can further reduce this pressure as desired. Additionally, the results point to the critical roles that particle size, release timing, and location play in distal embolization. Our study provides an early attempt to use patient-specific computer modeling for optimizing embolization strategies and ultimately improving patient outcomes during SAE procedures.
Competing Interests: Declaration of competing interest The authors hereby declare that they have no conflicts of interest.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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