PET/CT for the Opportunistic Screening of Osteoporosis and Fractures in Cancer Patients.

Autor: Park PSU; Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA. peter.park@pennmedicine.upenn.edu.; Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA. peter.park@pennmedicine.upenn.edu., Werner TJ; Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.; Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA., Alavi A; Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.; Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Jazyk: angličtina
Zdroj: Current osteoporosis reports [Curr Osteoporos Rep] 2024 Dec; Vol. 22 (6), pp. 553-560. Date of Electronic Publication: 2024 Sep 14.
DOI: 10.1007/s11914-024-00887-x
Abstrakt: Purpose of Review: In this review, we outline the different etiologies of osteoporosis in the oncologic setting and describe the basis for using PET/CT as screening tool for osteoporosis with a focus on the radiotracers [ 18 F]FDG and [ 18 F]NaF.
Recent Findings: Osteoporosis is a condition commonly affecting cancer patients due to their age, cancer-specific treatment agents, and effects of cancer. In terms of the unifying mechanism, decreased ratio of osteoblast-bone formation to osteoclast-bone resorption is responsible for causing osteoporosis. PET/CT, a crucial metabolic imaging modality in the oncologic imaging, could be a useful tool for the opportunistic screening of osteoporosis. There are two approaches with which osteoporosis could be identified with PET/CT-using either the (1) CT- based or (2) PET- based approaches. While the CT-based approach has been used with [ 18 F]FDG PET/CT, both CT- and PET-based approaches can be employed with [ 18 F]NaF-PET/CT as [ 18 F]NaF is a radiotracer specific for osteoblast activity.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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