| Autor: |
Green KA; School of Polymer Science and Engineering, The University of Southern Mississippi, Hattiesburg, Mississippi, Hattiesburg 39406, United States., Kulkarni AS; Department of Chemistry & Biochemistry, The Ohio State University, Columbus, Ohio 43210, United States.; William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, 151 W Woodruff Avenue, Columbus, Ohio 43210, United States., Jankoski PE; School of Polymer Science and Engineering, The University of Southern Mississippi, Hattiesburg, Mississippi, Hattiesburg 39406, United States., Newton TB; School of Polymer Science and Engineering, The University of Southern Mississippi, Hattiesburg, Mississippi, Hattiesburg 39406, United States., Derbigny B; Department of Chemistry & Biochemistry, The Ohio State University, Columbus, Ohio 43210, United States.; William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, 151 W Woodruff Avenue, Columbus, Ohio 43210, United States., Clemons TD; School of Polymer Science and Engineering, The University of Southern Mississippi, Hattiesburg, Mississippi, Hattiesburg 39406, United States., Watkins DL; Department of Chemistry & Biochemistry, The Ohio State University, Columbus, Ohio 43210, United States.; William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, 151 W Woodruff Avenue, Columbus, Ohio 43210, United States., Morgan SE; School of Polymer Science and Engineering, The University of Southern Mississippi, Hattiesburg, Mississippi, Hattiesburg 39406, United States. |
| Abstrakt: |
The self-assembly of Janus-type amphiphilic hybrid block copolymers composed of hydrophilic/hydrophobic layers has shown promise for drug encapsulation and delivery. Saccharides have previously been incorporated to improve the biocompatibility of self-assembled structures; however, glycopolymer block copolymers have been less explored, and their structure-property relationships are not well understood. In this study, novel glycopolymer-branched poly(lactic acid) (PLA) block copolymers were synthesized via thiol-ene coupling and their composition-dependent morphologies were elucidated. Stability as a function of pH, dye uptake capabilities, and cytotoxicity were evaluated. Systems with a hydrophilic weight ratio of 30% were found to produce bilayer nanoparticles, while systems with a hydrophilic weight ratio of 60% form micelles upon self-assembly in aqueous media. Regardless of composition and morphology, all systems exhibited uptake of both hydrophobic (curcumin, DL % from 4.25 to 11.55) and hydrophilic (methyl orange, DL % from 4.08 to 5.88) dye molecules with release profiles dependent on composition. Furthermore, all of the nanoparticles exhibited low cytotoxicity, confirming their potential for biomedical applications. |
