Incidentally Detected ALK-Positive Histiocytosis with EML4::ALK Fusion in a Solitary Pulmonary Nodule Following COVID-19 Infection: A Rare Case Report.

Autor:	Kolik AK; Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey., Bakkaloğlu DV; Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey., Yilmaz I; Department of Pathology, Sultan Abdulhamid Han Training & Research Hospital, University of Health Sciences, Istanbul, Turkey., Cakir MS; Department of Radiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey., Yegen G; Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey., Kara M; Department of Thoracic Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey., Özlük Y; Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Jazyk:	angličtina
Zdroj:	International journal of surgical pathology [Int J Surg Pathol] 2024 Sep 14, pp. 10668969241271372. Date of Electronic Publication: 2024 Sep 14.
DOI:	10.1177/10668969241271372
Abstrakt:	We hereby report a patient with ALK-positive histiocytosis with localized lung involvement. A 47-year-old woman presented with a solitary pulmonary nodule in the left upper lobe, 7 months after COVID infection. A well-defined 15 mm yellow mass was found in trisegmentectomy specimen. Histopathological examination revealed that the mass was composed of epithelioid and spindle cells with foamy cytoplasms. No necrosis, pleomorphism, or nuclear atypia was detected. The cells were positive for CD68, CD163, PU.1, ALK and negative for KRT, smooth muscle actin (SMA), S100, Melan-A, CD34, STAT6, and BRAF VE1. Flourescence in situ hybridization demonstrated ALK gene rearrangement, and next generation sequencing confirmed EML4::ALK fusion. Lung involvement in ALK-positive histiocytosis is characterized by the presence of pulmonary nodules, which can be seen in all forms of the disease. However, lung involvement is rarely seen in single-system ALK-positive histiocytosis. Our report represents the fourth documented instance of localized lung involvement in ALK-positive histiocytosis, an exceedingly rare occurrence, and it is the third instance with available molecular data. Competing Interests: Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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