Circulating Amino Acid Concentration after the Consumption of Pea or Whey Proteins in Young and Older Adults Affects Protein Synthesis in C2C12 Myotubes.

Autor:	Salles J; Unité de Nutrition Humaine (UNH), Université Clermont Auvergne, INRAE, CRNH Auvergne, 63000 Clermont-Ferrand, France., Gueugneau M; Unité de Nutrition Humaine (UNH), Université Clermont Auvergne, INRAE, CRNH Auvergne, 63000 Clermont-Ferrand, France., Laleg K; Unité de Nutrition Humaine (UNH), Université Clermont Auvergne, INRAE, CRNH Auvergne, 63000 Clermont-Ferrand, France., Giraudet C; Unité de Nutrition Humaine (UNH), Université Clermont Auvergne, INRAE, CRNH Auvergne, 63000 Clermont-Ferrand, France., Sanchez P; Unité de Nutrition Humaine (UNH), Université Clermont Auvergne, INRAE, CRNH Auvergne, 63000 Clermont-Ferrand, France., Blot A; CHU Clermont-Ferrand, Centre de Recherche en Nutrition Humaine Auvergne, 63000 Clermont-Ferrand, France., Richard R; CHU Clermont-Ferrand, Centre de Recherche en Nutrition Humaine Auvergne, 63000 Clermont-Ferrand, France., Neveux N; Service de Biochimie, Hôpital Cochin, APHP, Université Paris Centre, 75679 Paris CEDEX 14, France., Lefranc-Millot C; Life Sciences Research & Development, Nutrition & Health Department, Roquette, 62136 Lestrem, France., Perreau C; Life Sciences Research & Development, Nutrition & Health Department, Roquette, 62136 Lestrem, France., Guérin-Deremaux L; Life Sciences Research & Development, Nutrition & Health Department, Roquette, 62136 Lestrem, France., Boirie Y; Unité de Nutrition Humaine (UNH), Université Clermont Auvergne, INRAE, CRNH Auvergne, 63000 Clermont-Ferrand, France.; CHU Clermont-Ferrand, Service Nutrition Clinique, 63000 Clermont-Ferrand, France., Walrand S; Unité de Nutrition Humaine (UNH), Université Clermont Auvergne, INRAE, CRNH Auvergne, 63000 Clermont-Ferrand, France.; CHU Clermont-Ferrand, Service Nutrition Clinique, 63000 Clermont-Ferrand, France.
Jazyk:	angličtina
Zdroj:	Nutrients [Nutrients] 2024 Aug 27; Vol. 16 (17). Date of Electronic Publication: 2024 Aug 27.
DOI:	10.3390/nu16172870
Abstrakt:	As older adults tend to reduce their intake of animal-source proteins, plant-source proteins may offer valuable resources for better protein intake. The aim of this study was to assess whether the pea proteins can be used to achieve blood amino acid levels that stimulate muscle protein synthesis. We measured variations in plasma amino acid concentrations in young and older adults given pea (NUTRALYS ® S85 Plus) or whey proteins either alone or in a standardized meal. The effect of amino acid concentrations on protein synthesis in C2C12 myotubes was determined. In terms of results, plasma amino acid concentrations reflected the difference between the amino acid contents of whey and pea proteins. Blood leucine showed a greater increase of 91 to 130% with whey protein compared to pea protein, while the opposite was observed for arginine (A greater increase of 147 to 210% with pea compared to whey). Culture media prepared with plasmas from the human study induced age-dependent but not protein-type-dependent changes in myotube protein synthesis. In conclusion, pea and whey proteins have the same qualities in terms of their properties to maintain muscle protein synthesis. Pea proteins can be recommended for older people who do not consume enough animal-source proteins.
Databáze:	MEDLINE
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