Antibacterial Dental Adhesive Containing Cetylpyridinium Chloride Montmorillonite.

Autor: Okazaki Y; Department of Oral Health Sciences, BIOMAT, KU Leuven, 3000 Leuven, Belgium.; Department of Advanced Prosthodontics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan., Nakamori K; Department of Advanced Prosthodontics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan., Yao C; Department of Oral Health Sciences, BIOMAT, KU Leuven, 3000 Leuven, Belgium., Ahmed MH; Department of Oral Health Sciences, BIOMAT, KU Leuven, 3000 Leuven, Belgium., Mercelis B; Department of Oral Health Sciences, BIOMAT, KU Leuven, 3000 Leuven, Belgium., Nagaoka N; Advanced Research Center for Oral and Craniofacial Science, Okayama University Dental School, Okayama 700-8558, Japan., Maruo Y; Department of Prosthodontics, Okayama University, Okayama 700-8558, Japan., Yoshida Y; Department of Biomaterials and Bioengineering, Faculty of Dental Medicine, Hokkaido University, Sapporo 060-8586, Japan., Abe Y; Department of Advanced Prosthodontics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan., Van Meerbeek B; Department of Oral Health Sciences, BIOMAT, KU Leuven, 3000 Leuven, Belgium., Yoshihara K; Health and Medical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Takamatsu 761-0395, Japan.; Department of Pathology & Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.
Jazyk: angličtina
Zdroj: Materials (Basel, Switzerland) [Materials (Basel)] 2024 Sep 04; Vol. 17 (17). Date of Electronic Publication: 2024 Sep 04.
DOI: 10.3390/ma17174368
Abstrakt: Oral bacteria cause tooth caries and periodontal disease. Much research is being conducted to prevent both major oral diseases by rendering dental materials' antimicrobial potential. However, such antimicrobial materials are regarded as 'combination' products and face high hurdles for regulatory approval. We loaded inorganic montmorillonite with the antimicrobial agent cetylpyridinium chloride, referred to below as 'CPC-Mont'. CPC-Mont particles in a 1, 3 and 5 wt% concentration were added to the considered gold-standard self-etch adhesive Clearfil SE Bond 2 ('CSE2'; Kuraray Noritake) to render its antibacterial potential (CSE2 without CPC-Mont served as control). Besides measuring (immediate) bonding effectiveness and (aged) bond durability to dentin, the antibacterial activity against S. mutans and the polymerization-conversion rate was assessed. Immediate and aged bond strength was not affected by 1 and 3 wt% CPC-Mont addition, while 5 wt% CPC-Mont significantly lowered bond strength and bond durability. The higher the concentration of the antimicrobial material added, the stronger the antimicrobial activity. Polymerization conversion was not affected by the CPC-Mont addition in any of the three concentrations. Hence, adding 3 wt% CPC-Mont to the two-step self-etch adhesive rendered additional antimicrobial potential on top of its primary bonding function.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje