Clinical Risk Factors and First Gestational 75 g OGTT May Predict Recurrent and New-Onset Gestational Diabetes in Multiparous Women.

Autor: Mirabelli M; Department of Health Sciences, University 'Magna Græcia' of Catanzaro, 88100 Catanzaro, Italy.; Operative Unit of Endocrinology, 'Renato Dulbecco' University Hospital, 88100 Catanzaro, Italy., Tocci V; Department of Health Sciences, University 'Magna Græcia' of Catanzaro, 88100 Catanzaro, Italy.; Operative Unit of Endocrinology, 'Renato Dulbecco' University Hospital, 88100 Catanzaro, Italy., Chiefari E; Department of Health Sciences, University 'Magna Græcia' of Catanzaro, 88100 Catanzaro, Italy.; Operative Unit of Endocrinology, 'Renato Dulbecco' University Hospital, 88100 Catanzaro, Italy., Iuliano S; Department of Health Sciences, University 'Magna Græcia' of Catanzaro, 88100 Catanzaro, Italy., Brunetti FS; Department of Health Sciences, University 'Magna Græcia' of Catanzaro, 88100 Catanzaro, Italy., Misiti R; Operative Unit of Clinical Pathology, 'Renato Dulbecco' Hospital, 88100 Catanzaro, Italy.; Department of Experimental and Clinical Medicine, University 'Magna Græcia' of Catanzaro, 88100 Catanzaro, Italy., Giuliano S; Operative Unit of Endocrinology, 'Renato Dulbecco' University Hospital, 88100 Catanzaro, Italy., Greco M; Department of Health Sciences, University 'Magna Græcia' of Catanzaro, 88100 Catanzaro, Italy.; Department of Experimental and Clinical Medicine, University 'Magna Græcia' of Catanzaro, 88100 Catanzaro, Italy., Foti DP; Operative Unit of Clinical Pathology, 'Renato Dulbecco' Hospital, 88100 Catanzaro, Italy.; Department of Experimental and Clinical Medicine, University 'Magna Græcia' of Catanzaro, 88100 Catanzaro, Italy., Brunetti A; Department of Health Sciences, University 'Magna Græcia' of Catanzaro, 88100 Catanzaro, Italy.; Operative Unit of Endocrinology, 'Renato Dulbecco' University Hospital, 88100 Catanzaro, Italy.
Jazyk: angličtina
Zdroj: Journal of clinical medicine [J Clin Med] 2024 Sep 02; Vol. 13 (17). Date of Electronic Publication: 2024 Sep 02.
DOI: 10.3390/jcm13175200
Abstrakt: Background : Women who experience gestational diabetes mellitus (GDM) during their first pregnancy are at a high risk of developing GDM again in subsequent pregnancies. Even mothers with no previous history of GDM may develop the condition in a new pregnancy. Methods : In this retrospective cross-sectional observational study, 759 multiparous women tested for GDM in two successive pregnancies using the 75 g OGTT (IADPSG criteria) were enrolled. The OGTT was performed at 24-28 weeks' gestation or earlier if there was a history of GDM. Participants were categorized into four groups: women with normal glucose tolerance (NGT) in both pregnancies ( n = 493), women with a first occurrence of GDM in their second pregnancy ( n = 74), women with non-recurrent GDM in their second pregnancy ( n = 92), and women with recurrent GDM in their second pregnancy ( n = 100). Results : Intergroup comparisons revealed clinical predictors of GDM in the first pregnancy (family history of type 2 diabetes, PCOS, advanced maternal age, pregravid obesity) and in the second pregnancy (interpregnancy BMI gain), as well as predictors of recurrent GDM (pregravid obesity, PCOS). A positive correlation was observed between the OGTT glucose levels of consecutive pregnancies. Adjusted logistic regression indicated that a higher 1-h post-load glucose level (≥130 mg/dL) during the first pregnancy significantly increased the likelihood of new-onset GDM in the second pregnancy (OR: 2.496), whereas a higher 2-h post-load glucose level (≥153 mg/dL) at the first diagnostic OGTT increased the likelihood of recurrent GDM (OR: 2.214). Conclusions : Clinical risk factors and post-load glucose levels during the first gestational 75 g OGTT can help predict new-onset or recurrent GDM in multiparous women.
Databáze: MEDLINE
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