Ranolazine Unveiled: Rediscovering an Old Solution in a New Light.

Autor: De Santis GA; Cardiology Unit, Department of Clinical and Experimental Medicine, University of Messina, 98122 Messina, Italy., De Ferrari T; Cardiology Unit, Department of Clinical and Experimental Medicine, University of Messina, 98122 Messina, Italy., Parisi F; Clinical Cardiology and Heart Failure Unit, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT), 90127 Palermo, Italy., Franzino M; S.C. Cardiologia, Ospedale Sant'Andrea, 13100 Vercelli, Italy., Molinero AE; Cardiology Unit, Department of Clinical and Experimental Medicine, University of Messina, 98122 Messina, Italy., Di Carlo A; Cardiology Unit, Department of Clinical and Experimental Medicine, University of Messina, 98122 Messina, Italy., Pistelli L; Second Division of Cardiology, Cardio-Thoracic and Vascular Department, Pisa University Hospital, 56124 Pisa, Italy., Vetta G; Heart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel-Vrije Universiteit Brussel, European Reference Networks Guard-Heart, 1050 Brussels, Belgium., Parlavecchio A; Cardiology Unit, Department of Clinical and Experimental Medicine, University of Messina, 98122 Messina, Italy., Torre M; Second Division of Cardiology, Cardio-Thoracic and Vascular Department, Pisa University Hospital, 56124 Pisa, Italy., Parollo M; Second Division of Cardiology, Cardio-Thoracic and Vascular Department, Pisa University Hospital, 56124 Pisa, Italy., Mansi G; Second Division of Cardiology, Cardio-Thoracic and Vascular Department, Pisa University Hospital, 56124 Pisa, Italy., Tamborrino PP; Second Division of Cardiology, Cardio-Thoracic and Vascular Department, Pisa University Hospital, 56124 Pisa, Italy., Canu A; Second Division of Cardiology, Cardio-Thoracic and Vascular Department, Pisa University Hospital, 56124 Pisa, Italy., Grifoni G; Second Division of Cardiology, Cardio-Thoracic and Vascular Department, Pisa University Hospital, 56124 Pisa, Italy., Segreti L; Second Division of Cardiology, Cardio-Thoracic and Vascular Department, Pisa University Hospital, 56124 Pisa, Italy., Di Cori A; Second Division of Cardiology, Cardio-Thoracic and Vascular Department, Pisa University Hospital, 56124 Pisa, Italy., Viani SM; Second Division of Cardiology, Cardio-Thoracic and Vascular Department, Pisa University Hospital, 56124 Pisa, Italy., Zucchelli G; Second Division of Cardiology, Cardio-Thoracic and Vascular Department, Pisa University Hospital, 56124 Pisa, Italy.
Jazyk: angličtina
Zdroj: Journal of clinical medicine [J Clin Med] 2024 Aug 23; Vol. 13 (17). Date of Electronic Publication: 2024 Aug 23.
DOI: 10.3390/jcm13174985
Abstrakt: Ranolazine is an anti-anginal medication that has demonstrated antiarrhythmic properties by inhibiting both late sodium and potassium currents. Studies have shown promising results for ranolazine in treating both atrial fibrillation and ventricular arrhythmias, particularly when used in combination with other medications. This review explores ranolazine's mechanisms of action and its potential role in cardiac arrhythmias treatment in light of previous clinical studies.
Databáze: MEDLINE
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