| Autor: |
Díaz-García JD; División de Medicina Interna, Hospital General 'Dr. Manuel Gea González', Mexico City 14080, Mexico., Leyva-Leyva M; Departamento de Biología Molecular e Histocompatibilidad, Hospital General 'Dr. Manuel Gea González', Mexico City 14080, Mexico., Sánchez-Aguillón F; Departamento de Biología Molecular e Histocompatibilidad, Hospital General 'Dr. Manuel Gea González', Mexico City 14080, Mexico., de León-Bautista MP; Escuela de Medicina, Universidad Vasco de Quiroga, Morelia 58090, Mexico.; Laboratorio de Enfermedades Infecciosas y Genómica (INEX LAB), Morelia 58280, Mexico., Fuentes-Venegas A; División de Medicina Interna, Hospital General 'Dr. Manuel Gea González', Mexico City 14080, Mexico., Torres-Viloria A; División de Medicina Interna, Hospital General 'Dr. Manuel Gea González', Mexico City 14080, Mexico., Tenorio-Aguirre EK; División de Medicina Interna, Hospital General 'Dr. Manuel Gea González', Mexico City 14080, Mexico., Morales-Lázaro SL; División de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.; Centro de Investigación Sobre el Envejecimiento, CINVESTAV, Mexico City 14330, Mexico., Olivo-Díaz A; Departamento de Biología Molecular e Histocompatibilidad, Hospital General 'Dr. Manuel Gea González', Mexico City 14080, Mexico., González-Ramírez R; Departamento de Biología Molecular e Histocompatibilidad, Hospital General 'Dr. Manuel Gea González', Mexico City 14080, Mexico.; Centro de Investigación Sobre el Envejecimiento, CINVESTAV, Mexico City 14330, Mexico. |
| Abstrakt: |
Type 2 diabetes mellitus (T2DM) is a complex chronic disease characterized by decreased insulin secretion and the development of insulin resistance. Previous genome-wide association studies demonstrated that single-nucleotide polymorphisms (SNPs) present in genes coding for ion channels involved in insulin secretion increase the risk of developing this disease. We determined the association of 16 SNPs found in CACNA1D , KCNQ1 , KCNJ11 , and CACNA1E genes and the increased probability of developing T2DM. In this work, we performed a case-control study in 301 Mexican adults, including 201 cases with diabetes and 100 controls without diabetes. Our findings indicate a moderate association between T2DM and the C allele, and the C/C genotype of rs312480 within CACNA1D . The CAG haplotype surprisingly showed a protective effect, whereas the CAC and CGG haplotypes have a strong association with T2DM. The C allele and C/C genotype of rs5219 were significantly associated with diabetes. Also, an association was observed between diabetes and the A allele and the A/A genotype of rs3753737 and rs175338 in CACNA1E . The TGG and CGA haplotypes were also found to be significantly associated. The findings of this study indicate that the SNPs examined could serve as a potential diagnostic tool and contribute to the susceptibility of the Mexican population to this disease. |
