| Autor: |
Wang H; Department of Nutrition, Hung-Kuang University, Taichung 433304, Taiwan., Chan YL; Department of Life Science, Chinese Culture University, Taipei 111396, Taiwan., Chiu YH; Department of Microbiology, Soochow University, Taipei 111002, Taiwan., Wu TH; Division of Hemato-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Keelung 204006, Taiwan.; Department of Food Science and Center of Excellence for the Oceans, National Taiwan Ocean University, Keelung 202301, Taiwan., Hsia S; Taiwan Nutraceutical Association, Taipei 104483, Taiwan., Wu CJ; Department of Food Science and Center of Excellence for the Oceans, National Taiwan Ocean University, Keelung 202301, Taiwan.; Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung 807378, Taiwan. |
| Abstrakt: |
Lung cancer and cachexia are the leading causes of cancer-related deaths worldwide. Cachexia is manifested by weight loss and white adipose tissue (WAT) atrophy. Limited nutritional supplements are conducive to lung cancer patients, whereas the underlying mechanisms are poorly understood. In this study, we used a murine cancer cachexia model to investigate the effects of a nutritional formula (NuF) rich in fish oil and selenium yeast as an adjuvant to enhance the drug efficacy of an EGFR inhibitor (Tarceva). In contrast to the healthy control, tumor-bearing mice exhibited severe cachexia symptoms, including tissue wasting, hypoalbuminemia, and a lower food efficiency ratio. Experimentally, Tarceva reduced pEGFR and HIF-1α expression. NuF decreased the expression of pEGFR and HIF-2α, suggesting that Tarceva and NuF act differently in prohibiting tumor growth and subsequent metastasis. NuF blocked LLC tumor-induced PTHrP and expression of thermogenic factor UCP1 and lipolytic enzymes (ATGL and HSL) in WAT. NuF attenuated tumor progression, inhibited PTHrP-induced adipose tissue browning, and maintained adipose tissue integrity by modulating heat shock protein (HSP) 72. Added together, Tarceva in synergy with NuF favorably improves cancer cachexia as well as drug efficacy. |
