Impact of Cryopreserved Placental Allografts on Biochemical Recurrence in Prostate Cancer.

Autor: Gottlieb J; Department of Urologic Oncology, Providence Saint John's Cancer Institute, Santa Monica, CA 90404, USA., Hanes DA; Department of Biostatistics, Providence Saint Joseph Health Center, Portland, OR 97213, USA., Bustos MA; Department of Translational Molecular Medicine, Providence Saint John's Cancer Institute, Santa Monica, CA 90404, USA., Choe J; Department of Urologic Oncology, Providence Saint John's Cancer Institute, Santa Monica, CA 90404, USA., Luu A; Department of Urologic Oncology, Providence Saint John's Cancer Institute, Santa Monica, CA 90404, USA., Seizer D; Department of Urologic Oncology, Providence Saint John's Cancer Institute, Santa Monica, CA 90404, USA., Hoon DSB; Department of Translational Molecular Medicine, Providence Saint John's Cancer Institute, Santa Monica, CA 90404, USA., Wilson TG; Department of Urologic Oncology, Providence Saint John's Cancer Institute, Santa Monica, CA 90404, USA.
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2024 Aug 26; Vol. 16 (17). Date of Electronic Publication: 2024 Aug 26.
DOI: 10.3390/cancers16172973
Abstrakt: Background: Human placental allografts are widely used to promote wound healing. Placental (or amniotic membrane/umbilical cord) allografts are placed along the neurovascular bundles during radical prostatectomy to improve continence and erectile function recovery. It is unknown whether placental allografts impact biochemical recurrence (BCR).
Methods: This was a single-surgeon retrospective study of 566 robotic radical prostatectomies performed from April 2015 to March 2021. The patients were divided into three groups: the negative control, Brand A, and Brand B. Brand A and Brand B were both cryopreserved amniotic membrane (CAM) allografts. A total of 324 cases were included for BCR Kaplan-Meier and risk-adjusted multivariate analyses (362 for continence analysis). In vitro analyses were performed to determine the effect of CAM allografts on prostate cancer (PCa) cell line growth.
Results: For propensity score-matched analysis (adjusting for pre-operative PSA, tumor stage, Gleason Grade, and margin status), (1) the allograft groups did not show differences in time to BCR vs. the negative control group ( p = 0.7), and (2) combined allograft treatment groups showed better continence recovery vs. the negative controls ( p = 0.01). In vitro, placental allografts reduced PCa cell line growth in co-culture assays.
Conclusions: cryopreserved AM allografts (combined or individual brands) did not show a significant effect on BCR but improved continence recovery for PCa patients.
Databáze: MEDLINE
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