Chitosan-ricobendazole complex: Synthesis, characterization and anthelmintic activity.

Autor: Blinov A; North-Caucasus Federal University, Stavropol 355017, Russia., Orobets V; Stavropol State Agrarian University, Stavropol 355009, Russia., Kastarnova E; Stavropol State Agrarian University, Stavropol 355009, Russia., Gvozdenko A; North-Caucasus Federal University, Stavropol 355017, Russia., Golik A; North-Caucasus Federal University, Stavropol 355017, Russia., Rekhman Z; North-Caucasus Federal University, Stavropol 355017, Russia., Prasolova A; North-Caucasus Federal University, Stavropol 355017, Russia., Askerova A; North-Caucasus Federal University, Stavropol 355017, Russia., Kuznetsov E; North-Caucasus Federal University, Stavropol 355017, Russia., Nagdalian A; North-Caucasus Federal University, Stavropol 355017, Russia. Electronic address: anagdalian@ncfu.ru.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2024 Sep 11; Vol. 280 (Pt 1), pp. 135572. Date of Electronic Publication: 2024 Sep 11.
DOI: 10.1016/j.ijbiomac.2024.135572
Abstrakt: Synthesis, characterization and assessment of therapeutic efficacy of chitosan-ricobendazole complex were carried out for the first time in this work. Study of physico-chemical properties revealed the optimal ratio of chitosan: ricobendazole (30:4). Quantum chemical modeling set the optimal parameters for the formation of the chitosan-ricobendazole molecular system (E = -3765.26 kcal/mol, η = 0.127 eV), which was confirmed by Fourier-transform infrared spectroscopy. Scanning electron microscopy showed spherical particles of chitosan-ricobendazole complex ranging in size from 100 to 200 μm. Study of therapeutic efficiency was conducted on sheep with dicroceliosis. Notably, the therapeutic efficiency of the chitosan-ricobendazole complex (4 mg/kg of ricobendazole) reached 89 %, while the therapeutic efficiency of the commercial preparation ricazole (8 mg/kg of ricobendazole) was 92 %. Biochemical blood test indicated equivalent normalization of hematological parameters in sheep after treatment with ricazole and the chitosan-ricobendazole complex. Histological examination of infected sheep liver revealed that treatment with the chitosan-ricobendazole complex leads to a decrease in the number of helminth eggs with subsequent therapeutic effect on the severity of the disease. This proves the enhanced solubility of ricobendazole at a dosage of 4 mg/kg, active interaction of the components and relatively high bioavailability without increasing the release rate of ricobendazole.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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