Nanoscale fluconazole-constructed metal-organic frameworks with smart drug release for eradication of Candida biofilms in vulvovaginitis infection.

Autor: Wang J; The People's Hospital of Yuhuan, Yuhuan, Zhejiang 317600, China., Su L; State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Key Laboratory of Radiopharmacokinetics for Innovative Drugs, Tianjin Institutes of Health Science, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China. Electronic address: lz.su@irm-cams.ac.cn., Li Y; Translational Medicine Laboratory, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, China. Electronic address: yuanfengli@wmu.edu.cn., Liu Y; Wenzhou Institute, University of Chinese Academy of Sciences, Zhejiang 325001, China. Electronic address: y.liu@ucas.ac.cn., Xie L; The People's Hospital of Yuhuan, Yuhuan, Zhejiang 317600, China. Electronic address: lingpingxie@163.com.
Jazyk: angličtina
Zdroj: Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2025 Jan; Vol. 245, pp. 114238. Date of Electronic Publication: 2024 Sep 11.
DOI: 10.1016/j.colsurfb.2024.114238
Abstrakt: Fungal infections associated with oral, gynecological, and skin ailments pose significant clinical challenges. The presence of biofilms often hampers the efficacy of conventional antifungal drugs owing to the complex microenvironment they create. In this study, the widely used antifungal medication fluconazole is utilized as a foundational component to be incorporated into zinc 2-methylimidazolate frameworks, resulting in the synthesis of nanoscale fluconazole-constructed metal-organic frameworks (F-ZIF). The F-ZIF is constructed through coordination interactions between zinc and fluconazole, retaining the structure and pH-responsiveness of the zinc 2-methylimidazolate framework. The pH-responsiveness F-ZIF makes sure the fluconazole can be released in acidic biofilm, which prevents the undesired release in healthy tissue, resulting in good biocompatibility both in vitro and in vivo. The in vitro studies demonstrated that F-ZIF exhibits enhanced efficacy in eradicating fungal pathogens in their biofilm growth state compared with the free fluconazole. Furthermore, in vivo experiments reveal the better effectiveness of F-ZIF in treating Candida albicans-induced vulvovaginal candidiasis, and less infection-related inflammation was observed. Hence, the one-port synthetic F-ZIF presents a promising solution for addressing fungal biofilm-related infections.
Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Yong Liu serves as an editor of Colloids and Surfaces: B. However, he does not have access to manage the peer-review process until the submission deadline of June 11th, 2024, nor has he ever requested any inappropriate assistance in the review process. Yuanfeng Li serves on the editorial board of Colloids and Surfaces: B and she has never sought any inappropriate assistance from the journal in submitting the manuscript.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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