A promising therapeutic: Exosome-mediated mitochondrial transplantation.

Autor: Cao M; Department of Neonatology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, China., Zou J; Department of Pediatrics, The First Hospital of China Medical University, Shenyang, Liaoning 110001, China., Shi M; Department of Pediatrics, The First Hospital of China Medical University, Shenyang, Liaoning 110001, China., Zhao D; Department of Pediatrics, The First Hospital of China Medical University, Shenyang, Liaoning 110001, China., Liu C; Department of Pediatrics, The First Hospital of China Medical University, Shenyang, Liaoning 110001, China., Liu Y; Department of Pediatrics, The First Hospital of China Medical University, Shenyang, Liaoning 110001, China., Li L; Department of Orthopaedic Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, China. Electronic address: leilieieil@126.com., Jiang H; Department of Pediatrics, The First Hospital of China Medical University, Shenyang, Liaoning 110001, China. Electronic address: jianghongkun007@163.com.
Jazyk: angličtina
Zdroj: International immunopharmacology [Int Immunopharmacol] 2024 Dec 05; Vol. 142 (Pt A), pp. 113104. Date of Electronic Publication: 2024 Sep 12.
DOI: 10.1016/j.intimp.2024.113104
Abstrakt: Mitochondrial dysfunction has been identified as a trigger for cellular autophagy dysfunction and programmed cell death. Emerging studies have revealed that, in pathological contexts, intercellular transfer of mitochondria takes place, facilitating the restoration of mitochondrial function, energy metabolism, and immune homeostasis. Extracellular vesicles, membranous structures released by cells, exhibit reduced immunogenicity and enhanced stability during the transfer of mitochondria. Thus, this review provides a concise overview of mitochondrial dysfunction related diseases and the mechanism of mitochondrial dysfunction in diseases progression, and the composition and functions of the extracellular vesicles, along with elucidating the principal mechanisms underlying intercellular mitochondrial transfer. In this article, we will focus on the advancements in both animal models and clinical trials concerning the therapeutic efficacy of extracellular vesicle-mediated mitochondrial transplantation across various systemic diseases in neurodegenerative diseases and cardiovascular diseases. Additionally, the review delves into the multifaceted roles of extracellular vesicle-transplanted mitochondria, encompassing anti-inflammatory actions, promotion of tissue repair, enhancement of cellular function, and modulation of metabolic and immune homeostasis within diverse pathological contexts, aiming to provide novel perspectives for extracellular vesicle transplantation of mitochondria in the treatment of various diseases.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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