SIRT1 in acute lung injury: unraveling its pleiotropic functions and therapeutic development prospects.

Autor: Chen Y; Medical School, Hunan University of Chinese Medicine, Changsha, 410208, China., Peng S; Medical School, Hunan University of Chinese Medicine, Changsha, 410208, China., Liang J; Medical School, Hunan University of Chinese Medicine, Changsha, 410208, China., Wei K; Medical School, Hunan University of Chinese Medicine, Changsha, 410208, China. 004343@hnucm.edu.cn.; Hunan Province Key Laboratory of Integrative Pathogen Biology, Hunan University of Chinese Medicine, Changsha, 410208, Hunan, China. 004343@hnucm.edu.cn.
Jazyk: angličtina
Zdroj: Molecular and cellular biochemistry [Mol Cell Biochem] 2024 Sep 13. Date of Electronic Publication: 2024 Sep 13.
DOI: 10.1007/s11010-024-05111-z
Abstrakt: Acute lung injury (ALI) is a continuum of lung changes caused by multiple lung injuries, often associated with severe complications and even death. In ALI, macrophages, alveolar epithelial cells and vascular endothelial cells in the lung are damaged to varying degrees and their function is impaired. Research in recent years has focused on the use of SIRT1 for the treatment of ALI. In this paper, we reviewed the role of SIRT1 in ALI in terms of its cellular and molecular mechanism, targeting of SIRT1 by non-coding RNAs and drug components, as well as pointing out the value of SIRT1 for clinical diagnosis and prognosis. Based on the current literature, SIRT1 exhibits diverse functionalities and possesses significant therapeutic potential. Targeting SIRT1 may provide new therapeutic ideas for the treatment of ALI.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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