A novel internal target volume definition based on velocity and time of respiratory target motion for external beam radiotherapy.

Autor: Yamanaka M; Department of Medical Physics, Shonan Kamakura General Hospital, 1370-1 Okamoto, Kamakura City, Kanagawa, 247-8533, Japan.; Department of Medical Physics and Engineering, Osaka University Graduate School of Medicine, 1-7 Yamadaoka, Suita-Shi, Osaka, 565-0871, Japan., Nishio T; Department of Medical Physics and Engineering, Osaka University Graduate School of Medicine, 1-7 Yamadaoka, Suita-Shi, Osaka, 565-0871, Japan. nishio@sahs.med.osaka-u.ac.jp., Iwabuchi K; Mizuho Research & Technologies, Ltd., 2-3, Kanda-Nishikicho, Chiyoda-Ku, Tokyo, 101-8443, Japan., Nagata H; Department of Medical Physics, Shonan Kamakura General Hospital, 1370-1 Okamoto, Kamakura City, Kanagawa, 247-8533, Japan.
Jazyk: angličtina
Zdroj: Radiological physics and technology [Radiol Phys Technol] 2024 Dec; Vol. 17 (4), pp. 843-853. Date of Electronic Publication: 2024 Sep 13.
DOI: 10.1007/s12194-024-00837-3
Abstrakt: This study aimed to develop a novel internal target volume (ITV) definition for respiratory motion targets, considering target motion velocity and time. The proposed ITV was evaluated in respiratory-gated radiotherapy. An ITV modified with target motion velocity and time (ITVvt) was defined as an ITV that includes a target motion based on target motion velocity and time. The target motion velocity was calculated using four-dimensional computed tomography (4DCT) images. The ITVvts were created from phantom and clinical 4DCT images. The phantom 4DCT images were acquired using a solid phantom that moved with a sinusoidal waveform (peak-to-peak amplitudes of 10 and 20 mm and cycles of 2-6 s). The clinical 4DCT images were obtained from eight lung cancer cases. In respiratory-gated radiotherapy, the ITVvt was compared with conventional ITVs for beam times of 0.5-2 s within the gating window. The conventional ITV was created by adding a uniform margin as the maximum motion within the gating window. In the phantom images, the maximum volume difference between the ITVvt and conventional ITV was -81.9%. In the clinical images, the maximum volume difference was -53.6%. Shorter respiratory cycles and longer BTs resulted in smaller ITVvt compared with the conventional ITV. Therefore, the proposed ITVvt plan could be used to reduce treatment volumes and doses to normal tissues.
Competing Interests: Declarations. Conflict of interest: The authors have no conflict to disclose. Ethical approval: All procedures involving human participants were performed in accordance with the ethical standards of the Institutional Review Board and the 1964 Helsinki Declaration and its later amendments. Ethical approval was not required for this study as we used the clinical 4DCT images from an open database.
(© 2024. The Author(s), under exclusive licence to Japanese Society of Radiological Technology and Japan Society of Medical Physics.)
Databáze: MEDLINE
Externí odkaz: