Dehydrozingerone ameliorates arsenic-induced reproductive toxicity in male Wistar rats.

Autor: Choudhary A; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Hajipur, Export Promotions Industrial Park (EPIP), Industrial Area, Hajipur, Bihar, 844102, India., Pandey R; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Hajipur, Export Promotions Industrial Park (EPIP), Industrial Area, Hajipur, Bihar, 844102, India., Rathod D; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Hajipur, Export Promotions Industrial Park (EPIP), Industrial Area, Hajipur, Bihar, 844102, India., Sumalatha S; Department of Anatomy, Kasturbna Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India., Murti K; Department of Pharmacy Practice, National Institute of Pharmaceutical Education and Research, Hajipur, Export Promotions Industrial Park (EPIP), Industrial Area, Hajipur, Bihar, 844102, India., Ravichandiran V; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Hajipur, Export Promotions Industrial Park (EPIP), Industrial Area, Hajipur, Bihar, 844102, India., Kumar N; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Hajipur, Export Promotions Industrial Park (EPIP), Industrial Area, Hajipur, Bihar, 844102, India. niteshkumar43@gmail.com.
Jazyk: angličtina
Zdroj: Journal of molecular histology [J Mol Histol] 2024 Dec; Vol. 55 (6), pp. 1131-1145. Date of Electronic Publication: 2024 Sep 13.
DOI: 10.1007/s10735-024-10255-9
Abstrakt: Arsenic (As 3+ ), a significant environmental pollutant that has garnered global attention, is widely recognized for its adverse effects on reproductive health. This study assesses the aphrodisiac activity of Dehydrozingerone (DHZ) against As 3+ induced sexual dysfunction in male Wistar rats. Male Wistar rats were divided into control, As 3+ , and As 3+ +DHZ groups. The As 3+ group received 5 mg/kg sodium arsenite (NaAsO 2 ) orally while As 3+ +DHZ group received 50 mg/kg synthesized DHZ along with As 3+ for 42 days. Following administration, mount and intromission latency, frequency, and average time were measured to assess aphrodisiac and reproductive toxicity in male Wistar rats which had 1:1 coitus with female rats. On days 14th, 28th, and 42nd, sexual behaviour was measured. Further on 43rd day, animals were sacrificed, blood was collected to measure oxidative parameters and LH hormone, and then testes were collected to profile reproductive damage. As 3+ treated rats had lower sperm counts, motility, and abnormalities. These alterations reduced sexual hormones. In addition, As 3+ toxicity depleted antioxidant indicators including SOD, GSH and elevated ROS. Compared to the As 3+ group, As 3+ +DHZ showed a substantial (p < 0.05) increase in sperm count, motility, and reduced abnormalities. DHZ also reversed the rise in luteinizing hormone caused by As 3+ therapy, restored oxidative indicators, and improved seminiferous tubule structural damage. 42 days As 3+ exposure slightly increased rats' sexual desire but not sperm quality. However, As 3+ +DHZ lower libido and sperm quality. Thus, DHZ therapy enhanced rat sexual desire and sperm quality compared to As 3+ .
Competing Interests: Declarations Conflict of interest The authors declare no competing financial interests.
(© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)
Databáze: MEDLINE
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