Patient-reported disease control versus overall symptom severity as global metrics of chronic rhinosinusitis disease status.

Autor: Cotter RA; Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Garcia JT; Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Alsayed A; Department of Otolaryngology--Head and Neck Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia., Schneider S; Department of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria., Liu DT; Department of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria., Eckl-Dorna J; Department of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria., Houssein FA; Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Boparai RS; University of Nevada, Reno School of Medicine, Reno, Nevada, USA., Parail NA; Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Chu MM; Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Meier JC; University of Nevada, Reno School of Medicine, Reno, Nevada, USA.; Nevada ENT and Hearing Associates, Reno, Nevada, USA., Alsaleh S; Department of Otolaryngology--Head and Neck Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia., Phillips KM; Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Sedaghat AR; Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Jazyk: angličtina
Zdroj: International forum of allergy & rhinology [Int Forum Allergy Rhinol] 2025 Jan; Vol. 15 (1), pp. 27-35. Date of Electronic Publication: 2024 Sep 13.
DOI: 10.1002/alr.23435
Abstrakt: Background: Overall symptom severity (OSS) and patient-reported chronic rhinosinusitis (CRS) control are global measures of CRS identified as consensus, essential criteria for CRS disease control assessment. We sought to determine the functional relationship between these two metrics.
Methods: Using an international multicenter mixed-methods design, 260 CRS patients were recruited. OSS score was measured using a visual analog scale. Patient-reported CRS control was measured as "controlled," "partly controlled," and "uncontrolled." Twelve participants underwent semi-structured interviews to discuss OSS and patient-reported CRS control.
Results: The majority of interviewed participants felt OSS and patient-reported CRS control measured different constructs-while OSS only measured symptoms, patient-reported CRS control was more global, including not only symptom severity but also concepts such as medication usage, activity impairment, and exacerbations. Nevertheless, OSS score was strongly correlated with (ρ = 0.67, p < 0.001) and highly predictive of patient-reported CRS control. OSS score of >4 (95% confidence interval [CI]: 1.8-4.2) had 74.7% sensitivity and 93.2% specificity in identifying patients reporting their CRS as not controlled. OSS score of >6.6 (95% CI: 4.1-7.1) had 77.0% sensitivity and 75.9% specificity in identifying patients reporting their CRS as uncontrolled. The 22-item Sinonasal Outcome Test score was also predictive of patient-reported CRS disease control but OSS was significantly more predictive.
Conclusions: Patients conceptually view patient-reported CRS control as a more global measure that subsumes OSS. Quantitatively, however, OSS is highly correlated with patient-reported CRS control, possibly reflecting their redundancy. For ease of use, we recommend patient-reported CRS control be reflected by OSS <4 for controlled, 4 ≤ OSS < 7 for partly controlled, and OSS ≥7 for uncontrolled CRS.
(© 2024 The Author(s). International Forum of Allergy & Rhinology published by Wiley Periodicals LLC on behalf of American Academy of Otolaryngic Allergy and American Rhinologic Society.)
Databáze: MEDLINE
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