Neutrophil phenotype, effector functions and microbicidal activity in SARS-CoV-2-associated ARDS patients.

Autor:	Quelven Q; Infectious Diseases and Intensive Care Unit, Pontchaillou University Hospital, 2 rue Henri Le Guilloux, 35033 Rennes, France.; SITI, Pole de Biologie, Pontchaillou University Hospital, Etablissement Français du Sang Bretagne, 2 rue Henri Le Guilloux, 35033 Rennes, France.; UMR 1236, Univ Rennes, INSERM, Etablissement Français du Sang Bretagne, Rennes, France., Grégoire M; SITI, Pole de Biologie, Pontchaillou University Hospital, Etablissement Français du Sang Bretagne, 2 rue Henri Le Guilloux, 35033 Rennes, France.; UMR 1236, Univ Rennes, INSERM, Etablissement Français du Sang Bretagne, Rennes, France., Coirier V; Infectious Diseases and Intensive Care Unit, Pontchaillou University Hospital, 2 rue Henri Le Guilloux, 35033 Rennes, France.; SITI, Pole de Biologie, Pontchaillou University Hospital, Etablissement Français du Sang Bretagne, 2 rue Henri Le Guilloux, 35033 Rennes, France.; UMR 1236, Univ Rennes, INSERM, Etablissement Français du Sang Bretagne, Rennes, France., Gacouin A; Infectious Diseases and Intensive Care Unit, Pontchaillou University Hospital, 2 rue Henri Le Guilloux, 35033 Rennes, France., Le Gallou S; SITI, Pole de Biologie, Pontchaillou University Hospital, Etablissement Français du Sang Bretagne, 2 rue Henri Le Guilloux, 35033 Rennes, France.; UMR 1236, Univ Rennes, INSERM, Etablissement Français du Sang Bretagne, Rennes, France., Cattoir V; Laboratory of Bacteriology, Pontchaillou University Hospital, 2 rue Henri Le Guilloux, 35033 Rennes, France., Cogné M; SITI, Pole de Biologie, Pontchaillou University Hospital, Etablissement Français du Sang Bretagne, 2 rue Henri Le Guilloux, 35033 Rennes, France.; UMR 1236, Univ Rennes, INSERM, Etablissement Français du Sang Bretagne, Rennes, France., Guegan H; Laboratory of Mycology, Pontchaillou University Hospital, 2 rue Henri Le Guilloux, 35033 Rennes, France., Gangneux JP; Laboratory of Mycology, Pontchaillou University Hospital, 2 rue Henri Le Guilloux, 35033 Rennes, France., Roussel M; SITI, Pole de Biologie, Pontchaillou University Hospital, Etablissement Français du Sang Bretagne, 2 rue Henri Le Guilloux, 35033 Rennes, France.; UMR 1236, Univ Rennes, INSERM, Etablissement Français du Sang Bretagne, Rennes, France., Tarte K; SITI, Pole de Biologie, Pontchaillou University Hospital, Etablissement Français du Sang Bretagne, 2 rue Henri Le Guilloux, 35033 Rennes, France.; UMR 1236, Univ Rennes, INSERM, Etablissement Français du Sang Bretagne, Rennes, France., Tadié JM; Infectious Diseases and Intensive Care Unit, Pontchaillou University Hospital, 2 rue Henri Le Guilloux, 35033 Rennes, France.; SITI, Pole de Biologie, Pontchaillou University Hospital, Etablissement Français du Sang Bretagne, 2 rue Henri Le Guilloux, 35033 Rennes, France.; UMR 1236, Univ Rennes, INSERM, Etablissement Français du Sang Bretagne, Rennes, France., Lesouhaitier M; Infectious Diseases and Intensive Care Unit, Pontchaillou University Hospital, 2 rue Henri Le Guilloux, 35033 Rennes, France.; SITI, Pole de Biologie, Pontchaillou University Hospital, Etablissement Français du Sang Bretagne, 2 rue Henri Le Guilloux, 35033 Rennes, France.; UMR 1236, Univ Rennes, INSERM, Etablissement Français du Sang Bretagne, Rennes, France.
Jazyk:	angličtina
Zdroj:	Journal of leukocyte biology [J Leukoc Biol] 2024 Sep 12. Date of Electronic Publication: 2024 Sep 12.
DOI:	10.1093/jleuko/qiae195
Abstrakt:	Critically ill patients admitted to the intensive care unit (ICU) for SARS-CoV-2-induced acute respiratory distress syndrome (ARDS) are at increased risk of bacterial and fungal secondary pulmonary infections due to acquired immune dysfunction. Given that the activity of neutrophils has not been described in these patients, we aimed to investigate the function of neutrophils at ICU admission and on Day 7 (D7) post admission. Neutrophil maturation and several functional indicators were investigated. We detected a significant decrease in reactive oxygen species production at D7, but we did not observe any other significant alterations in neutrophil function. Furthermore, bronchoalveolar lavage obtained from patients displayed no inhibitory effect on the function of neutrophils from healthy donors. These findings indicate that patients admitted to the ICU for SARS-CoV-2-induced ARDS do not acquire neutrophil dysfunction within the first week of their stay, which suggests that nosocomial infections among these patients are not due to acquired neutrophil dysfunctions. (© The Author(s) 2024. Published by Oxford University Press on behalf of Society for Leukocyte Biology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)
Databáze:	MEDLINE
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