Helicobacter pylori infection is associated with liver fibrosis in patients with obesity undergoing bariatric surgery.

Autor: Córdova-Gallardo J; Facultad de Medicina Universidad Nacional Autonoma de Mexico Coyoacán Mexico.; Department of Hepatology Hospital General 'Dr. Manuel Gea González' Tlalpan Mexico., Martínez-Sánchez FD; Facultad de Medicina Universidad Nacional Autonoma de Mexico Coyoacán Mexico.; Department of Internal Medicine Hospital General 'Dr. Manuel Gea González' Tlalpan Mexico., Medina-Julio D; Facultad de Medicina Universidad Nacional Autonoma de Mexico Coyoacán Mexico.; Department of Internal Medicine Hospital General 'Dr. Manuel Gea González' Tlalpan Mexico., Rojano-Rodríguez ME; Department of Bariatric Surgery Hospital General 'Dr. Manuel Gea González' Tlalpan Mexico., Romero-Loera LS; Department of Bariatric Surgery Hospital General 'Dr. Manuel Gea González' Tlalpan Mexico., Vargas-Agredano R; Department of Bariatric Surgery Hospital General 'Dr. Manuel Gea González' Tlalpan Mexico., Méndez-Sánchez N; Facultad de Medicina Universidad Nacional Autonoma de Mexico Coyoacán Mexico.; Liver Research Unit Medica Sur Clinic & Foundation Ciudad de México Mexico.
Jazyk: angličtina
Zdroj: JGH open : an open access journal of gastroenterology and hepatology [JGH Open] 2024 Sep 12; Vol. 8 (9), pp. e70023. Date of Electronic Publication: 2024 Sep 12 (Print Publication: 2024).
DOI: 10.1002/jgh3.70023
Abstrakt: Background: Obesity is a significant risk factor for metabolic-associated steatotic liver disease (MASLD). The association between Helicobacter pylori (HP) infection and liver fibrosis has not been fully elucidated in patients with obesity and MASLD.
Methods: This observational retrospective study included clinical and biochemical parameters of patients with obesity undergoing bariatric surgery. HP infection was confirmed by gastric endoscopy, and liver biopsies were performed during surgery. Bivariate and logistic regression analyses were employed to evaluate independent associations with liver fibrosis and steatosis by biopsy.
Results: The mean age of the subjects was 42 ± 10 years, with 84.7% being women, and they had a mean BMI of 42.97 ± 7.56 kg/m2. Overall, 41.7% of patients had an HP infection. Multiple logistic regression models were conducted to assess the association between HP infection, liver steatosis, and fibrosis by biopsy. HP infection was independently associated with liver fibrosis [OR = 3.164 (95% CI 1.011-9.900)].
Conclusion: Biopsy findings associated HP infection with increased liver fibrosis.
(© 2024 The Author(s). JGH Open published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
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