Plasma concentrations of IL-6, MIP-1β, IP-10, and PTX-3 as predictors of the immunological response to antiretroviral treatment in people with HIV.

Autor:	Mejías-Trueba M; Department of Pharmacy, University Hospital Virgen del Rocío, Seville, Spain.; Clinical Unit of Infectious Diseases, Clinical Microbiology and Parasitology. Institute of Biomedicine of Seville/Virgen del Rocio University Hospital/CSIC/University of Seville, Seville, Spain., Saborido-Alconchel A; Clinical Unit of Infectious Diseases, Clinical Microbiology and Parasitology. Institute of Biomedicine of Seville/Virgen del Rocio University Hospital/CSIC/University of Seville, Seville, Spain., Serna-Gallego A; Clinical Unit of Infectious Diseases, Clinical Microbiology and Parasitology. Institute of Biomedicine of Seville/Virgen del Rocio University Hospital/CSIC/University of Seville, Seville, Spain., Trujillo-Rodríguez M; Clinical Unit of Infectious Diseases, Clinical Microbiology and Parasitology. Institute of Biomedicine of Seville/Virgen del Rocio University Hospital/CSIC/University of Seville, Seville, Spain., Muñoz-Muela E; Clinical Unit of Infectious Diseases, Clinical Microbiology and Parasitology. Institute of Biomedicine of Seville/Virgen del Rocio University Hospital/CSIC/University of Seville, Seville, Spain., Llaves-Flores S; Clinical Unit of Infectious Diseases, Clinical Microbiology and Parasitology. Institute of Biomedicine of Seville/Virgen del Rocio University Hospital/CSIC/University of Seville, Seville, Spain., Espinosa N; Clinical Unit of Infectious Diseases, Clinical Microbiology and Parasitology. Institute of Biomedicine of Seville/Virgen del Rocio University Hospital/CSIC/University of Seville, Seville, Spain., Roca-Oporto C; Clinical Unit of Infectious Diseases, Clinical Microbiology and Parasitology. Institute of Biomedicine of Seville/Virgen del Rocio University Hospital/CSIC/University of Seville, Seville, Spain., Herrero M; Clinical Unit of Infectious Diseases, Clinical Microbiology and Parasitology. Institute of Biomedicine of Seville/Virgen del Rocio University Hospital/CSIC/University of Seville, Seville, Spain., Sotomayor C; Clinical Unit of Infectious Diseases, Clinical Microbiology and Parasitology. Institute of Biomedicine of Seville/Virgen del Rocio University Hospital/CSIC/University of Seville, Seville, Spain., López-Cortes LF; Clinical Unit of Infectious Diseases, Clinical Microbiology and Parasitology. Institute of Biomedicine of Seville/Virgen del Rocio University Hospital/CSIC/University of Seville, Seville, Spain.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2024 Aug 29; Vol. 15, pp. 1447926. Date of Electronic Publication: 2024 Aug 29 (Print Publication: 2024).
DOI:	10.3389/fimmu.2024.1447926
Abstrakt:	Despite effective antiretroviral therapy (ART), 15-30% of people with HIV experience poor CD4 + T-cell recovery, termed immunologic non-responders (INR). This study aims to evaluate whether pre-ART plasma levels of interleukin-6 (IL-6), interferon gamma-induced protein-10 (IP-10), macrophage inflammatory protein-1-β (MIP-1β), and/or pentraxin-3 (PTX-3) could predict subsequent immunologic recovery. Seventy-four participants were enrolled and classified as INR and immunologic responders (IR) based on CD4 + /CD8 + ratio increase over 24 months after starting ART. The results showed no significant differences in cytokine levels between INR and IR. Therefore, IL-6, IP-10, MIP-1β, and PTX-3 were unsuitable as predictive markers of poor immune recovery. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Mejías-Trueba, Saborido-Alconchel, Serna-Gallego, Trujillo-Rodríguez, Muñoz-Muela, Llaves-Flores, Espinosa, Roca-Oporto, Herrero, Sotomayor and López-Cortes.)
Databáze:	MEDLINE
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