Elevated plasma levels of IP-10 and MIG are early predictors of loss of control among elite HIV controllers.

Autor:	Poveda E; Group of Virology and Pathogenesis, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Vigo, Spain., Fitzgerald W; Section on Intercellular Interactions, Eunice Kennedy Shriver National Institutes of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States., Alonso-Domínguez J; Group of Virology and Pathogenesis, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Vigo, Spain., Aguayo-Arjona J; Statistics and Methodology Unit, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Vigo, Spain., Mariño A; Complexo Hospitalario Universitario de Ferrol, Sergas, A Coruña, Spain., Álvarez H; Complexo Hospitalario Universitario de Ferrol, Sergas, A Coruña, Spain., Valcarce N; Complexo Hospitalario Universitario de Ferrol, Sergas, A Coruña, Spain., Pérez A; Group of Virology and Pathogenesis, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Vigo, Spain., Ruiz-Mateos E; Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, Clinical Unit of Infectious Diseases, Microbiology and Parasitology, University of Seville, Seville, Spain., Margolis L; Faculty of Natural Sciences and Medicine, Ilia State University, Tbilisi, Georgia., Lederman MM; Department of Medicine, Case Western Reserve University, Cleveland, OH, United States., Freeman ML; Department of Medicine, Case Western Reserve University, Cleveland, OH, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2024 Aug 29; Vol. 15, pp. 1446730. Date of Electronic Publication: 2024 Aug 29 (Print Publication: 2024).
DOI:	10.3389/fimmu.2024.1446730
Abstrakt:	Plasma cytokine levels were quantified among 30 persons with HIV (PWH) identified as elite controllers (15 transient controllers [studied a median of 1.38 years before losing viral control] and 15 persistent controllers). Thirty antiretroviral therapy (ART)-naive PWH, 30 ART-treated PWH with undetectable viremia, and 30 HIV-uninfected controls also were studied. Higher levels of cytokines were recognized among PWH than among controls, with EC displaying the highest levels. Elevated levels of IP-10 and MIG were identified among transient controllers as predictors of the loss of viral control. These findings offer feasible biomarkers for predicting virologic outcome and loss of control in EC. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision (Copyright © 2024 Poveda, Fitzgerald, Alonso-Domínguez, Aguayo-Arjona, Mariño, Álvarez, Valcarce, Pérez, Ruiz-Mateos, Margolis, Lederman and Freeman.)
Databáze:	MEDLINE
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