Nebulized inhalation of plasma-activated water in the treatment of progressive moderate COVID-19 patients with antiviral treatment failure: a randomized controlled pilot trial.

Autor: Zhao H; Department of Respiratory and Critical Care Medicine, Xijing Hospital of Air Force Medical University, Xi'an, 710032, China., Meng W; Department of Respiratory and Critical Care Medicine, Xijing Hospital of Air Force Medical University, Xi'an, 710032, China., Lv X; Department of Respiratory and Critical Care Medicine, Xijing Hospital of Air Force Medical University, Xi'an, 710032, China., Li J; Department of Respiratory and Critical Care Medicine, Xijing Hospital of Air Force Medical University, Xi'an, 710032, China., Cai Z; Department of Respiratory and Critical Care Medicine, Xijing Hospital of Air Force Medical University, Xi'an, 710032, China., Guo X; Department of Respiratory and Critical Care Medicine, Xijing Hospital of Air Force Medical University, Xi'an, 710032, China., Wang Z; State Key Laboratory of Electrical Insulation and Power Equipment, Center for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an, 710049, China., Guo L; State Key Laboratory of Electrical Insulation and Power Equipment, Center for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an, 710049, China., Rong M; State Key Laboratory of Electrical Insulation and Power Equipment, Center for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an, 710049, China., Shen C; Department of PET-CT, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China., Liu D; State Key Laboratory of Electrical Insulation and Power Equipment, Center for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an, 710049, China. liudingxin@mail.xjtu.edu.cn., Song L; Department of Respiratory and Critical Care Medicine, Xijing Hospital of Air Force Medical University, Xi'an, 710032, China. songlq@fmmu.edu.cn.
Jazyk: angličtina
Zdroj: BMC infectious diseases [BMC Infect Dis] 2024 Sep 12; Vol. 24 (1), pp. 960. Date of Electronic Publication: 2024 Sep 12.
DOI: 10.1186/s12879-024-09886-w
Abstrakt: Background: Antiviral drugs show significant efficacy in non-severe COVID-19 cases, yet there remains a subset of moderate COVID-19 patients whose pneumonia continues to progress post a complete course of treatment. Plasma-activated water (PAW) possesses anti-SARS-CoV-2 properties. To explore the potential of PAW in improving pneumonia in COVID-19 patients following antiviral treatment failure, we conducted this study.
Methods: This was a randomized, controlled trial. Moderate COVID-19 patients with antiviral treatment failure were randomly assigned to the experimental group or the control group. They inhaled nebulized PAW or saline respectively. This was done twice daily for four consecutive days. We assessed improvement in chest CT on day 5, the rate of symptom resolution within 10 days, and safety.
Results: A total of 23 participants were included, with 11 receiving PAW and 12 receiving saline. The baseline characteristics of both groups were comparable. The experimental group showed a higher improvement rate in chest CT on day 5 (81.8% vs. 33.3%, p = 0.036). The cumulative disappearance rate of cough within 10 days was higher in the experimental group. Within 28 days, 4 patients in each group progressed to severe illness, and no patients died. No adverse reactions were reported from inhaling nebulized PAW.
Conclusion: This pilot trial preliminarily confirmed that nebulized inhalation of PAW can alleviate pneumonia in moderate COVID-19 patients with antiviral treatment failure, with no adverse reactions observed. This still needs to be verified by large-scale studies.
Trial Registration: Chinese Clinical Trial Registry; No.: ChiCTR2300078706 (retrospectively registered, 12/15/2023); URL: www.chictr.org.cn .
(© 2024. The Author(s).)
Databáze: MEDLINE
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