Predictors of mortality and severe illness from Escherichia coli sepsis in neonates.

Autor: Hoffman A; Rainbow Babies and Children's Hospital, Case Western Reserve University School of Medicine, Cleveland, OH, USA., Satyavolu S; Case Cardiovascular Research Institute, Cleveland, OH, USA., Muhanna D; Case Western Reserve University School of Medicine, Cleveland, OH, USA., Malay S; Rainbow Babies and Children's Hospital, Case Western Reserve University School of Medicine, Cleveland, OH, USA., Raffay T; Rainbow Babies and Children's Hospital, Case Western Reserve University School of Medicine, Cleveland, OH, USA., Windau A; Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, OH, USA., Ransom EM; Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.; Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA., Mukherjee D; Rainbow Babies and Children's Hospital, Case Western Reserve University School of Medicine, Cleveland, OH, USA. Devashis.Mukherjee@uhhospitals.org.
Jazyk: angličtina
Zdroj: Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2024 Dec; Vol. 44 (12), pp. 1816-1821. Date of Electronic Publication: 2024 Sep 12.
DOI: 10.1038/s41372-024-02117-9
Abstrakt: Neonatal Escherichia coli (E. coli) sepsis is increasing. There is limited data on the factors contributing to increased mortality and severity of illness in neonatal E. coli sepsis. A retrospective review of neonates (<30 days) admitted to a Level IV NICU in the United States from 2008 to 2022 diagnosed with E. coli bloodstream or cerebrospinal fluid infection was conducted. Primary outcome was defined as mortality from or severe illness during E. coli infection (defined as a need for inotropic support or metabolic acidosis). E. coli neonatal sepsis rate increased from 2008 to 2022 (average of 1.12 per 1000 live births). The primary outcome, which occurred in 57.4% of cases, was independently associated with prematurity, neutropenia, and thrombocytopenia. Ampicillin resistance was not associated with the primary outcome. GA, neutropenia, and thrombocytopenia but not ampicillin resistance, are associated with mortality or severe illness from E. coli sepsis.
Competing Interests: Competing interests: The authors declare no conflicts of interest. Ethics approval and consent to participate: This study was performed in accordance with the Declaration of Helsinki. The Institutional Review Board at University Hospitals Cleveland Medical Center approved this study (20221171) and waived the need to obtain informed consent from study participants due to its retrospective nature. All methods were performed according to institutional guidelines and regulations.
(© 2024. The Author(s).)
Databáze: MEDLINE
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