Differential Social Cognitive Performance in Older Adults With Mild Cognitive Impairment and Dementia.

Autor:	Chander RJ; Centre for Healthy Brain Ageing (RJC, KN, RC, KAM, NAK, HB, PSS), Discipline of Psychiatry & Mental Health, School of Clinical Medicine , Faculty of Medicine & Health, University of New South Wales, Sydney, New South Wales, Australia. Electronic address: r.chander@unsw.edu.au., Numbers K; Centre for Healthy Brain Ageing (RJC, KN, RC, KAM, NAK, HB, PSS), Discipline of Psychiatry & Mental Health, School of Clinical Medicine , Faculty of Medicine & Health, University of New South Wales, Sydney, New South Wales, Australia., Grainger SA; School of Psychology (SAG, JDH), University of Queensland, St Lucia Queensland, Australia., Cleary R; Centre for Healthy Brain Ageing (RJC, KN, RC, KAM, NAK, HB, PSS), Discipline of Psychiatry & Mental Health, School of Clinical Medicine , Faculty of Medicine & Health, University of New South Wales, Sydney, New South Wales, Australia., Mather KA; Centre for Healthy Brain Ageing (RJC, KN, RC, KAM, NAK, HB, PSS), Discipline of Psychiatry & Mental Health, School of Clinical Medicine , Faculty of Medicine & Health, University of New South Wales, Sydney, New South Wales, Australia., Kochan NA; Centre for Healthy Brain Ageing (RJC, KN, RC, KAM, NAK, HB, PSS), Discipline of Psychiatry & Mental Health, School of Clinical Medicine , Faculty of Medicine & Health, University of New South Wales, Sydney, New South Wales, Australia., Brodaty H; Centre for Healthy Brain Ageing (RJC, KN, RC, KAM, NAK, HB, PSS), Discipline of Psychiatry & Mental Health, School of Clinical Medicine , Faculty of Medicine & Health, University of New South Wales, Sydney, New South Wales, Australia; Dementia Collaborative Research Centre (HB), School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia; Academic Department for Old Age Psychiatry (HB), Prince of Wales Hospital, Randwick, New South Wales, Australia., Henry JD; School of Psychology (SAG, JDH), University of Queensland, St Lucia Queensland, Australia., Sachdev PS; Centre for Healthy Brain Ageing (RJC, KN, RC, KAM, NAK, HB, PSS), Discipline of Psychiatry & Mental Health, School of Clinical Medicine , Faculty of Medicine & Health, University of New South Wales, Sydney, New South Wales, Australia; Neuropsychiatric Institute (PSS), Prince of Wales Hospital, Randwick, New South Wales, Australia.
Jazyk:	angličtina
Zdroj:	The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry [Am J Geriatr Psychiatry] 2024 Aug 24. Date of Electronic Publication: 2024 Aug 24.
DOI:	10.1016/j.jagp.2024.08.008
Abstrakt:	Objective: To study general and subdomain performance in measures of social cognition in individuals with mild cognitive impairment (MCI), and dementia, and to explore associations between social cognitive and neuropsychological subdomains. Design: Cross-sectional study of participants from the Sydney Memory and Ageing Study (MAS). Setting: Current data was collected in 2016-2018. Participants: Community-dwelling older adults (n=321) aged 80 years and above, with no history of neurological or psychiatric conditions. Participants had dementia, MCI, or no cognitive impairment (NCI). Measures: Social cognition was indexed using the Reading the Mind in the Eyes Test (RMET), the Interpersonal Reactivity Index - Perspective Taking (IRI-PT) and Empathic Concern (IRI-EC) subscales, and the Emotion Recognition Task (ERT). These subdomain scores were used to make a composite social cognition score. Apathy was measured via the Apathy Evaluation Scale (AES). Neurocognitive function was indexed using the Addenbrooke Cognitive Examination v3 (ACE-3). Results: Dementia was associated with poorer overall social cognitive composite performance. MCI and dementia participants performed poorer on RMET and recognition of anger, disgust and happiness on ERT. RMET and ERT disgust remained significant after controlling for relevant covariates. Dementia participants performed poorer than MCI and NCI on the IRI-PT, IRI-EC, and AES. AES remained significant after regression. RMET was correlated with ACE-3 Fluency and/or Language in all study groups. Conclusions: MCI is associated with poorer scores in specific social cognitive assessments. Dementia is somewhat associated with poorer scores in informant-rated social cognition scales, though this is no longer significant after accounting for apathy. Competing Interests: DISCLOSURES The Sydney MAS was supported by two National Health and Medical Research Council of Australia grants: Program Grant (350833) and Capacity Building Grant (568940). This study was also additionally supported by the Australian Research Council Discovery Project Grant (DP170101239). J.D.H is currently supported by an Australian Research Council Future Fellowship (FT170100096). R.J.C. was supported by the University of New South Wales Scientia PhD Scholarship Program. The authors report no conflicts of interest. The authors thank all current and former study team members of Sydney MAS for their invaluable work and guidance, as well as all study participants for volunteering their time and effort to take part in this study. We would also like to thank John Crawford for his guidance on this analysis. The authors report no conflicts with any product mentioned or concept discussed in this article. (Copyright © 2024 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu