Diagnostic Accuracy of [ 18 F]FDG PET/MRI in Head and Neck Squamous Cell Carcinoma: A Systematic Review and Metaanalysis.

Autor:	Al-Ibraheem A; Department of Nuclear Medicine, King Hussein Cancer Center, Amman, Jordan; aibraheem@khcc.jo.; School of Medicine, University of Jordan, Amman, Jordan., Abdlkadir A; Department of Nuclear Medicine, King Hussein Cancer Center, Amman, Jordan., Herrmann K; Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany.; German Cancer Consortium, Partner Site University Hospital Essen, Essen, Germany., Bomanji J; Institute of Nuclear Medicine, University College London, London, United Kingdom., Jadvar H; Division of Nuclear Medicine and Molecular Imaging, Keck School of Medicine, University of Southern California, Los Angeles, California., Shi H; Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, Shanghai, China., Mansour A; Department of Radiology, King Hussein Cancer Center, Amman, Jordan., Paez D; Nuclear Medicine and Diagnostic Imaging Section, International Atomic Energy Agency, Vienna, Austria., Chiti A; Department of Nuclear Medicine, IRCCS Ospedale San Raffaele, Milan, Italy., Scott AM; Department of Molecular Imaging and Therapy, Austin Health, Heidelberg, Victoria, Australia.; Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia; and.; Olivia Newton-John Cancer Research Institute and La Trobe University, Heidelberg, Victoria, Australia.
Jazyk:	angličtina
Zdroj:	Journal of nuclear medicine : official publication, Society of Nuclear Medicine [J Nucl Med] 2024 Oct 01; Vol. 65 (10), pp. 1533-1539. Date of Electronic Publication: 2024 Oct 01.
DOI:	10.2967/jnumed.124.268049
Abstrakt:	This study evaluates the diagnostic utility of PET/MRI for primary, locoregional, and nodal head and neck squamous cell carcinoma (HNSCC) through systematic review and metaanalysis. Methods: A systematic search was conducted using PubMed and Scopus to identify studies on the diagnostic accuracy of PET/MRI for HNSCC. The search included specific terms and excluded nonhybrid PET/MRI studies, and those with a sample size of fewer than 10 patients were excluded. Results: In total, 15 studies encompassing 638 patients were found addressing the diagnostic test accuracy for PET/MRI within the chosen subject domain. Squamous cell carcinoma of the nasopharynx was the most observed HNSCC subtype ( n = 198). The metaanalysis included 12 studies, with pooled sensitivity and specificity values of 93% and 95% per patient for primary disease evaluation, 93% and 96% for locoregional evaluation, and 89% and 98% per lesion for nodal disease detection, respectively. An examination of a subset of studies comparing PET/MRI against PET/CT or MRI alone for evaluating nodal and locoregional HNSCC found that PET/MRI may offer slightly higher accuracy than other modalities. However, this difference was not statistically significant. Conclusion: PET/MRI has excellent potential for identifying primary, locoregional, and nodal HNSCC. (© 2024 by the Society of Nuclear Medicine and Molecular Imaging.)
Databáze:	MEDLINE
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