Clinical, radiological, and pathological features of mitotically active cellular fibroma of ovary: A review of cases with literature review.

Autor:	Kim ET; Department of Obstetrics and Gynecology, Kosin University Gospel Hospital, Busan, South Korea., Song YJ; Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Busan, South Korea; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, South Korea., Park KY; Department of Obstetrics and Gynecology, Kosin University Gospel Hospital, Busan, South Korea., Hwang CS; Department of Pathology, Pusan National University School of Medicine, Busan, South Korea., Lee NK; Department of Radiology, Pusan National University School of Medicine, Busan, South Korea., Roh HJ; Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, South Korea., Suh DS; Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Busan, South Korea; Biomedical Research Institute, Pusan National University Hospital, Busan, South Korea., Kim KH; Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Busan, South Korea; Biomedical Research Institute, Pusan National University Hospital, Busan, South Korea. Electronic address: ghkim@pusan.ac.kr.
Jazyk:	angličtina
Zdroj:	Taiwanese journal of obstetrics & gynecology [Taiwan J Obstet Gynecol] 2024 Sep; Vol. 63 (5), pp. 722-730.
DOI:	10.1016/j.tjog.2024.04.016
Abstrakt:	Objective: Mitotically active cellular fibroma (MACF) of the ovary, characterized by relatively high mitotic activity without severe atypia, was first described in the WHO classification in 2014. However, due to its rarity, the clinicopathological characteristics of ovarian MACF have not been established. This study was performed to describe the clinical, radiological, and pathological features of MACF by analyzing 11 cases of ovarian MACF. Materials and Methods: Between 2015 and 2022, 11 patients with ovarian MACFs underwent surgical treatment at our institution. Clinicopathologic data of the patients were retrospectively reviewed from their medical records. Results: Median patient age was 53.7 years (range 21-77 years), and median tumor diameter was 7.8 cm (range 4.3-14.0 cm). Preoperative CA125 was elevated in 4 cases. Four of the eleven patients had abdominal pain, and two presented with vulvar pain or a palpable abdominal mass, respectively. Preoperative radiological impressions included fibroma, fibrothecoma, stromal tumor, and cystadenocarcinoma. A laparoscopic approach was adopted in 7 cases (64%). Intraoperative frozen section was performed in 5 patients, and all demonstrated the presence of a benign, fibromatous stromal tumor. Three patients underwent fertility-sparing surgery, including laparoscopic ovarian cystectomy and unilateral salpingo-oophorectomy. Median follow-up was 37.7 months (range 2-84 months), and no patient experienced disease relapse or died of their disease. Conclusion: This study shows that ovarian MACF has a benign clinical course. Fertility-sparing surgery provides a safe therapeutic option for MACF, which can be managed safely by laparoscopy. Imaging findings and final pathological diagnosis were not well matched. Intraoperative frozen section is important for determining surgical extent in mitotically active cellular fibroma of the ovary. Competing Interests: Conflicts of interest The authors declare no conflicts of interest related to this manuscript. (Copyright © 2024. Published by Elsevier B.V.)
Databáze:	MEDLINE
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