An examination of the methods and variables used in experimental design that impact the toxicological outcomes of e-cigarettes.

Autor: Beard JM; Department of Biology, Baylor University, Waco, TX, 76798-7266, USA., Sayes CM; Department of Biology, Baylor University, Waco, TX, 76798-7266, USA; Department of Environmental Science, Baylor University, Waco, TX, 76798-7266, USA. Electronic address: Christie_sayes@baylor.edu.
Jazyk: angličtina
Zdroj: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2024 Nov; Vol. 193, pp. 114999. Date of Electronic Publication: 2024 Sep 10.
DOI: 10.1016/j.fct.2024.114999
Abstrakt: A clear answer on whether vaping is safe and, if not, to what degree it threatens human health and well-being, still needs to be communicated. Such an answer requires collecting, analyzing, and interpreting sometimes conflicting and indeterminate results. This paper reviews the most recently published research articles that examine vaping toxicities. It highlights the differences in the techniques employed from one paper to another. While e-cigarettes do not appear to cause the same degree of harm as cigarettes, they pose a real biological threat regarding inflammation, oxidative stress, mucociliary interference, and membrane damage. The concentration of nicotine present is directly related to these endpoints and is often higher in fourth-generation devices. However, third-generation devices can do more harm than their successors, possibly due to their high voltage and low resistance capabilities. In addition to nicotine, the flavorants used in e-cigarettes have also been shown to relate to biological stress, and the adverse health effects increase in vape formulations with higher concentrations and numbers of flavor types. Different biological models also yield different health effects, especially when comparing bronchial and alveolar cells or tissues. To universalize the results of vape experiments, researchers should seek greater consistency within the experimental design. Key methodological variables must be recognized and disclosed in future research, including puff duration and number, types of e-cigarettes and e-liquids being tested, device settings during aerosolization, and any details of the employed exposure method that may affect dosimetry.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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