Tamsulosin and Time to Spontaneous Void After Hysterectomy: A Randomized Controlled Trial.
| Autor: | Gabra M; Department of Obstetrics and Gynecology, Banner-University of Arizona Medical Center, the University of Arizona College of Medicine, and the Epidemiology and Biostatistics Department, University of Arizona College of Public Health, Tucson, and the Department of Obstetrics and Gynecology, Banner-University of Arizona Medical Center, Phoenix, Arizona., Hall C, McCann L, Shah J, Jones I, Masjedi A, Runke S, Hsu CH, Aguirre A |
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| Jazyk: | angličtina |
| Zdroj: | Obstetrics and gynecology [Obstet Gynecol] 2024 Dec 01; Vol. 144 (6), pp. 810-816. Date of Electronic Publication: 2024 Sep 12. |
| DOI: | 10.1097/AOG.0000000000005724 |
| Abstrakt: | Objective: To evaluate whether a single preoperative dose of tamsulosin reduces the time to postoperative void and time to discharge in patients who are undergoing minimally invasive hysterectomy. Methods: This single-center, block-randomized, placebo-controlled, double-blind superiority trial evaluated the effect of 0.4 mg tamsulosin compared with placebo on the time to void after hysterectomy. Patients who underwent outpatient minimally invasive hysterectomy were randomized to a single dose of tamsulosin or placebo 1 hour before surgery. All participants underwent a standardized backfill void trial to eliminate discrepancies in bladder volume that would otherwise affect the time to void. For our primary aim, we planned to enroll 150 participants to show a 30-minute reduction in the time to postoperative void (80% power, α<0.05). The secondary aim was to compare the time to discharge from the postanesthesia care unit. Results: From June 2021 through January 2023, 344 patients were screened, and 150 were included in the final data analysis: 77 in the tamsulosin group and 73 in the placebo group. The time to spontaneous void was not different between the tamsulosin and placebo groups (106 minutes vs 100 minutes, P =.5). In addition, there was no statistical difference in time to discharge from the postanesthesia care unit (144 minutes vs 156 minutes, P =.4). Demographics and surgical details were not different between each group. Conclusion: A single dose of tamsulosin preoperatively does not lead to a decrease in postoperative time to void or time to discharge in patients undergoing minimally invasive hysterectomy for benign conditions. Clinical Trial Registration: ClinicalTrials.gov , NCT04859660. Competing Interests: Financial Disclosure The authors did not report any potential conflicts of interest. (Copyright © 2024 by the American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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