Effect of Polysaccharides Isolated from Saussurea salicifolia (L.) DC on Th2-Dependent Immune Response.

Autor: Ligacheva AA; Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia., Danilets MG; Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia., Gulina EI; Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia., Selivanova NS; Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.; Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia., Trofimova ES; Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia. trofimova_es@pharmso.ru.; Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia. trofimova_es@pharmso.ru., Sherstoboev EY; Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia., Avdeeva EY; Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia., Reshetov YE; Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia., Krivoshchekov SV; Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia., Zhdanov VV; Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia., Belousov MV; Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2024 Aug; Vol. 177 (4), pp. 470-475. Date of Electronic Publication: 2024 Sep 12.
DOI: 10.1007/s10517-024-06210-z
Abstrakt: The effect of polysaccharides isolated from the aboveground parts of Saussurea salicifolia (L.) DC on Th2 type immune response reactions was studied. Administration of water-soluble polysaccharides presented by arabino-galacturonans (weight average molecular weight 158.49 kDa) to mice against the background of experimental Th2 immunity reduced the severity of anaphylactic and local immediate type hypersensitivity reactions. It also suppressed the production of ovalbumin-specific IgE and IgG1 and increased the stability of mast cell membranes. The studied polysaccharide complex increased IFNγ secretion and inhibited IL-4 synthesis. These findings suggest that these polysaccharides may be considered as potential anti-allergic agents that suppress the development of allergy in its early stages.
(© 2024. Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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