The Influence of Metabolites of Microorganisms of the Genus Bacillus from Permafrost Rocks on T Lymphocyte Differentiation.

Autor: Petrov SA; Federal Research Centre Tyumen Scientific Centre, Siberian Branch of the Russian Academy of Sciences, Tyumen, Russia. tumiki@yandex.ru., Sukovey YG; Federal Research Centre Tyumen Scientific Centre, Siberian Branch of the Russian Academy of Sciences, Tyumen, Russia., Kalenova LF; Federal Research Centre Tyumen Scientific Centre, Siberian Branch of the Russian Academy of Sciences, Tyumen, Russia., Kostolomova EG; Tyumen State Medical University, Ministry of Health of the Russian Federation, Tyumen, Russia., Subbotin AM; Federal Research Centre Tyumen Scientific Centre, Siberian Branch of the Russian Academy of Sciences, Tyumen, Russia., Narushko MV; Federal Research Centre Tyumen Scientific Centre, Siberian Branch of the Russian Academy of Sciences, Tyumen, Russia., Bazhin AS; Federal Research Centre Tyumen Scientific Centre, Siberian Branch of the Russian Academy of Sciences, Tyumen, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2024 Aug; Vol. 177 (4), pp. 488-492. Date of Electronic Publication: 2024 Sep 12.
DOI: 10.1007/s10517-024-06212-x
Abstrakt: We studied the influence of metabolites of permafrost microorganisms obtained at different temperature incubation conditions on activity of differentiation of regulatory (Treg) and effector T lymphocytes. It was found that the effect of metabolites is largely regulated by their type that depends on the temperature of production ("cold" at 5°C, "medium temperature" at 22°C, and "warm" at 37°C). The studied metabolites influenced the differentiation of Tregs (CD4 + CD25 hi CD127 - ) and the expression of markers of early (CD69), middle (CD25), and late (HLA DR) activation of CD4 + and CD8 + T lymphocytes. In the case of "cold" metabolites, the increase in Treg levels was associated with a decrease in the intensity of CD4 + T lymphocyte differentiation, and under the influence of "warm" metabolites - with a decrease in the activity of CD8 + T lymphocyte differentiation. Under the influence of "medium-temperature" metabolites, Tregs had approximately the same effect on the intensity of CD4 + and CD8 + T lymphocyte differentiation.
(© 2024. Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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