Dysmetabolism of Peripheral Blood Monocytes in Type 1 Diabetes Mellitus.

Autor: Ivanov VV; Siberian State Medical University, Ministry of Health of Russia, Tomsk, Russia. ivanovvv1953@gmail.com., Buyko EE; Siberian State Medical University, Ministry of Health of Russia, Tomsk, Russia., Ufandeev AA; Siberian State Medical University, Ministry of Health of Russia, Tomsk, Russia., Nevskaya KV; Siberian State Medical University, Ministry of Health of Russia, Tomsk, Russia., Slavkina YS; Siberian State Medical University, Ministry of Health of Russia, Tomsk, Russia., Udut EV; Siberian State Medical University, Ministry of Health of Russia, Tomsk, Russia., Saprina TV; Siberian State Medical University, Ministry of Health of Russia, Tomsk, Russia., Udut VV; Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2024 Aug; Vol. 177 (4), pp. 423-426. Date of Electronic Publication: 2024 Sep 12.
DOI: 10.1007/s10517-024-06201-0
Abstrakt: The level of ROS (fluorescent probe 2',7'-dichlorodihydrofluorescein diacetate) and lipid content (fluorescent lipophilic dye Nile Red) in the peripheral blood monocyte fraction from patients with type 1 diabetes mellitus and healthy volunteers were assessed by flow cytofluorimetry. The number of CD36 + monocytes was assessed using specific antibodies. In patients with type 1 diabetes mellitus, the levels of ROS and intracellular lipids in monocytes and the number of cells expressing CD36 fatty acid translocase were elevated. These results indicate metabolic changes in the peripheral blood cells of patients with carbohydrate metabolism disorders and can be considered as possible prognostic markers for the development of type 1 diabetes mellitus complications.
(© 2024. Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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