A Passive Perspiration Inspired Wearable Platform for Continuous Glucose Monitoring.

Autor: Saha T; Aiiso Yufeng Li Family Department of Chemical and Nanoengineering, University of California San Diego, La Jolla, CA, 92093, USA., Khan MI; Aiiso Yufeng Li Family Department of Chemical and Nanoengineering, University of California San Diego, La Jolla, CA, 92093, USA., Sandhu SS; Aiiso Yufeng Li Family Department of Chemical and Nanoengineering, University of California San Diego, La Jolla, CA, 92093, USA., Yin L; Aiiso Yufeng Li Family Department of Chemical and Nanoengineering, University of California San Diego, La Jolla, CA, 92093, USA., Earney S; Aiiso Yufeng Li Family Department of Chemical and Nanoengineering, University of California San Diego, La Jolla, CA, 92093, USA., Zhang C; Aiiso Yufeng Li Family Department of Chemical and Nanoengineering, University of California San Diego, La Jolla, CA, 92093, USA., Djassemi O; Aiiso Yufeng Li Family Department of Chemical and Nanoengineering, University of California San Diego, La Jolla, CA, 92093, USA.; Department of Bioengineering, University of California San Diego, La Jolla, CA, 92093, USA., Wang Z; Department of Mechanical Engineering, University of California San Diego, La Jolla, CA, 92093, USA., Han J; Department of Mechanical Engineering, University of California San Diego, La Jolla, CA, 92093, USA., Abdal A; Department of Mechanical Engineering, University of California San Diego, La Jolla, CA, 92093, USA., Srivatsa S; Department of Bioengineering, University of California San Diego, La Jolla, CA, 92093, USA., Ding S; Aiiso Yufeng Li Family Department of Chemical and Nanoengineering, University of California San Diego, La Jolla, CA, 92093, USA., Wang J; Aiiso Yufeng Li Family Department of Chemical and Nanoengineering, University of California San Diego, La Jolla, CA, 92093, USA.
Jazyk: angličtina
Zdroj: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Sep 12, pp. e2405518. Date of Electronic Publication: 2024 Sep 12.
DOI: 10.1002/advs.202405518
Abstrakt: The demand for glucose monitoring devices has witnessed continuous growth from the rising diabetic population. The traditional approach of blood glucose (BG) sensor strip testing generates only intermittent glucose readings. Interstitial fluid-based devices measure glucose dynamically, but their sensing approaches remain either minimally invasive or prone to skin irritation. Here, a sweat glucose monitoring system is presented, which completely operates under rest with no sweat stimulation and can generate real-time BG dynamics. Osmotically driven hydrogels, capillary action with paper microfluidics, and self-powered enzymatic biochemical sensor are used for simultaneous sweat extraction, transport, and glucose monitoring, respectively. The osmotic forces facilitate greater flux inflow and minimize sweat rate fluctuations compared to natural perspiration-based sampling. The epidermal platform is tested on fingertip and forearm under varying physiological conditions. Personalized calibration models are developed and validated to obtain real-time BG information from sweat. The estimated BG concentration showed a good correlation with measured BG concentration, with all values lying in the A+B region of consensus error grid (MARD = 10.56% (fingertip) and 13.17% (forearm)). Overall, the successful execution of such osmotically driven continuous BG monitoring system from passive sweat can be a useful addition to the next-generation continuous sweat glucose monitors.
(© 2024 The Author(s). Advanced Science published by Wiley‐VCH GmbH.)
Databáze: MEDLINE
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