Lewis base promoted [4 + 2] annulation of o -acylamino-aryl MBH carbonates with isatin.

Autor:	Shen LW; Department of Chemistry and Chemical Engineering, Zunyi Normal College, Zunyi 563002, China. shenlw1994@163.com., Luo N; Department of Chemistry and Chemical Engineering, Zunyi Normal College, Zunyi 563002, China. shenlw1994@163.com., Jia YQ; Department of Chemistry and Chemical Engineering, Zunyi Normal College, Zunyi 563002, China. shenlw1994@163.com., Wang GW; Department of Chemistry and Chemical Engineering, Zunyi Normal College, Zunyi 563002, China. shenlw1994@163.com., Yuan SP; School of Chemistry and Chemical Engineering, Shaanxi Normal University, Shaanxi 710119, China., Xiang M; Department of Chemistry and Chemical Engineering, Zunyi Normal College, Zunyi 563002, China. shenlw1994@163.com.
Jazyk:	angličtina
Zdroj:	Organic & biomolecular chemistry [Org Biomol Chem] 2024 Oct 09; Vol. 22 (39), pp. 7961-7964. Date of Electronic Publication: 2024 Oct 09.
DOI:	10.1039/d4ob01240b
Abstrakt:	The first example of Lewis base promoted [4 + 2] annulation between o -acylamino-aryl MBH carbonates and isatin has been developed. This methodology exhibits excellent substrate applicability and has synthesized 1,4-dihydrospiro benzo[ d ][1,3]oxazine-oxindoles with yields up to 98%. The practical value of this method is underscored by its successful application in a 50-fold scale-up.
Databáze:	MEDLINE
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