Pera orange juice ( Citrus sinensis L. Osbeck ) alters lipid metabolism and attenuates oxidative stress in the heart and liver of rats treated with doxorubicin.

Autor: Cabral RP; Botucatu Bioscience Institute, São Paulo State University (Unesp), Brazil., Ribeiro APD; Botucatu Medical School, São Paulo State University (Unesp), Brazil., Monte MG; Botucatu Medical School, São Paulo State University (Unesp), Brazil., Fujimori ASS; Botucatu Medical School, São Paulo State University (Unesp), Brazil., Tonon CR; Botucatu Medical School, São Paulo State University (Unesp), Brazil., Ferreira NF; Botucatu Medical School, São Paulo State University (Unesp), Brazil., Zanatti SG; Botucatu Medical School, São Paulo State University (Unesp), Brazil., Minicucci MF; Botucatu Medical School, São Paulo State University (Unesp), Brazil., Zornoff LAM; Botucatu Medical School, São Paulo State University (Unesp), Brazil., Paiva SAR; Botucatu Medical School, São Paulo State University (Unesp), Brazil., Polegato BF; Botucatu Medical School, São Paulo State University (Unesp), Brazil.
Jazyk: angličtina
Zdroj: Heliyon [Heliyon] 2024 Aug 23; Vol. 10 (17), pp. e36834. Date of Electronic Publication: 2024 Aug 23 (Print Publication: 2024).
DOI: 10.1016/j.heliyon.2024.e36834
Abstrakt: Background: Doxorubicin (DOX) is a highly effective chemotherapy drug widely used to treat cancer, but its use is limited due to multisystemic toxicity. Lipid metabolism is also affected by doxorubicin. Orange juice can reduce dyslipidemia in other clinical situations and has already been shown to attenuate cardiotoxicity. Our aim is to evaluate the effects of Pera orange juice ( Citrus sinensis L. Osbeck ) on mitigating lipid metabolism imbalance, metabolic pathways, and DOX induced cytotoxic effects in the heart and liver.
Methods: Twenty-four male Wistar rats were allocated into 3 groups: Control (C); DOX (D); and DOX plus Pera orange juice (DOJ). DOJ received orange juice for 4 weeks, while C and D received water. At the end of each week, D and DOJ groups received 4 mg/kg/week DOX, intraperitoneal. At the end of 4 weeks animals were submitted to echocardiography and euthanasia.
Results: Animals treated with DOX decreased water intake and lost weight over time. At echocardiography, DOX treated rats presented morphologic alterations in the heart. DOX increased aspartate aminotransferase (AST), alanine aminotransferase (ALT), total cholesterol, high density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides. It also reduced superoxide dismutase (SOD) activity, increased protein carbonylation in the heart and dihydroethidium (DHE) expression in the liver, decreased glucose transporter type 4 (GLUT4) and the nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ 1 ) in the heart, and reduced carnitine palmitoyltransferase I (CPT1) in the liver.
Conclusion: DOX caused dyslipidemia, liver and cardiac toxicity by increasing oxidative stress, and altered energy metabolic parameters in both organs. Despite not improving changes in left ventricular morphology, orange juice did attenuate oxidative stress and mitigate the metabolic effects of DOX.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2024 The Authors.)
Databáze: MEDLINE
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