Real-time fMRI neurofeedback modulates induced hallucinations and underlying brain mechanisms.

Autor: Dhanis H; Neuro-X Institute, Ecole Polytechnique Fédérale de Lausanne, Geneva, Switzerland.; Brain Mind Institute, Faculty of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland., Gninenko N; Neuro-X Institute, Ecole Polytechnique Fédérale de Lausanne, Geneva, Switzerland.; Department of Radiology and Medical Informatics, University of Geneva, Geneva, Switzerland.; Department of Neurology, Inselspital, University Hospital of Bern, Bern, Switzerland., Morgenroth E; Neuro-X Institute, Ecole Polytechnique Fédérale de Lausanne, Geneva, Switzerland.; Department of Radiology and Medical Informatics, University of Geneva, Geneva, Switzerland., Potheegadoo J; Neuro-X Institute, Ecole Polytechnique Fédérale de Lausanne, Geneva, Switzerland.; Brain Mind Institute, Faculty of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland., Rognini G; Neuro-X Institute, Ecole Polytechnique Fédérale de Lausanne, Geneva, Switzerland.; Brain Mind Institute, Faculty of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland., Faivre N; Neuro-X Institute, Ecole Polytechnique Fédérale de Lausanne, Geneva, Switzerland.; Brain Mind Institute, Faculty of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.; Univ. Grenoble Alpes, Univ. Savoie Mont Blanc, CNRS, LPNC, Grenoble, France., Blanke O; Neuro-X Institute, Ecole Polytechnique Fédérale de Lausanne, Geneva, Switzerland. olaf.blanke@epfl.ch.; Brain Mind Institute, Faculty of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. olaf.blanke@epfl.ch.; Department of Clinical Neurosciences, University Hospital of Geneva, Geneva, Switzerland. olaf.blanke@epfl.ch., Van De Ville D; Neuro-X Institute, Ecole Polytechnique Fédérale de Lausanne, Geneva, Switzerland. dimitri.vandeville@epfl.ch.; Department of Radiology and Medical Informatics, University of Geneva, Geneva, Switzerland. dimitri.vandeville@epfl.ch.
Jazyk: angličtina
Zdroj: Communications biology [Commun Biol] 2024 Sep 11; Vol. 7 (1), pp. 1120. Date of Electronic Publication: 2024 Sep 11.
DOI: 10.1038/s42003-024-06842-x
Abstrakt: Hallucinations can occur in the healthy population, are clinically relevant and frequent symptoms in many neuropsychiatric conditions, and have been shown to mark disease progression in patients with neurodegenerative disorders where antipsychotic treatment remains challenging. Here, we combine MR-robotics capable of inducing a clinically-relevant hallucination, with real-time fMRI neurofeedback (fMRI-NF) to train healthy individuals to up-regulate a fronto-parietal brain network associated with the robotically-induced hallucination. Over three days, participants learned to modulate occurrences of and transition probabilities to this network, leading to heightened sensitivity to induced hallucinations after training. Moreover, participants who became sensitive and succeeded in fMRI-NF training, showed sustained and specific neural changes after training, characterized by increased hallucination network occurrences during induction and decreased hallucination network occurrences during a matched control condition. These data demonstrate that fMRI-NF modulates specific hallucination network dynamics and highlights the potential of fMRI-NF as a novel antipsychotic treatment in neurodegenerative disorders and schizophrenia.
(© 2024. The Author(s).)
Databáze: MEDLINE
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