Stress increases sperm respiration and motility in mice and men.

Autor: Moon N; Department of Psychiatry, University of Colorado Anschutz Medical Campus School of Medicine, Aurora, CO, 80045, USA.; Department of Pharmacology, University of Maryland Baltimore, Baltimore, MD, 21201, USA., Morgan CP; Department of Pharmacology, University of Maryland Baltimore, Baltimore, MD, 21201, USA., Marx-Rattner R; Department of Pharmacology, University of Maryland Baltimore, Baltimore, MD, 21201, USA., Jeng A; Department of Psychiatry, University of Colorado Anschutz Medical Campus School of Medicine, Aurora, CO, 80045, USA., Johnson RL; Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA., Chikezie I; Department of Pharmacology, University of Maryland Baltimore, Baltimore, MD, 21201, USA., Mannella C; Department of Physiology, University of Maryland Baltimore, Baltimore, MD, 21201, USA., Sammel MD; Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA., Epperson CN; Department of Psychiatry, University of Colorado Anschutz Medical Campus School of Medicine, Aurora, CO, 80045, USA., Bale TL; Department of Psychiatry, University of Colorado Anschutz Medical Campus School of Medicine, Aurora, CO, 80045, USA. tracy.bale@cuanschutz.edu.; Department of Pharmacology, University of Maryland Baltimore, Baltimore, MD, 21201, USA. tracy.bale@cuanschutz.edu.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 Sep 11; Vol. 15 (1), pp. 7900. Date of Electronic Publication: 2024 Sep 11.
DOI: 10.1038/s41467-024-52319-0
Abstrakt: Semen quality and fertility has declined over the last 50 years, corresponding to ever-increasing environmental stressors. However, the cellular mechanisms involved and their impact on sperm functions remain unknown. In a repeated sampling human cohort study, we identify a significant effect of prior perceived stress to increase sperm motility 2-3 months following stress, timing that expands upon our previous studies revealing significant stress-associated changes in sperm RNA important for fertility. We mechanistically examine this post-stress timing in mice using an in vitro stress model in the epididymal epithelial cells responsible for sperm maturation and find 7282 differentially H3K27me3 bound DNA regions involving genes critical for mitochondrial and metabolic pathways. Further, prior stress exposure significantly changes the composition and size of epithelial cell-secreted extracellular vesicles that when incubated with mouse sperm, increase mitochondrial respiration and sperm motility, adding to our prior work showing impacts on embryo development. Together, these studies identify a time-dependent, translational signaling pathway that communicates stress experience to sperm, ultimately affecting reproductive functions.
(© 2024. The Author(s).)
Databáze: MEDLINE
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